J Reconstr Microsurg 2019; 35(04): 263-269
DOI: 10.1055/s-0038-1675146
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Long-Term Outcome after Successful Lower Extremity Free Flap Salvage

Amir K. Bigdeli
1   Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany
,
Emre Gazyakan
1   Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany
,
Volker J. Schmidt
1   Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany
,
Christoph Bauer
1   Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany
,
Günter Germann
2   Clinic for Plastic, Reconstructive and Aesthetic Surgery, Ethianum Hospital at University of Heidelberg, Heidelberg, Germany
,
Christian A. Radu
1   Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany
,
Ulrich Kneser
1   Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany
,
Christoph Hirche
1   Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany
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Weitere Informationen

Publikationsverlauf

27. März 2018

08. September 2018

Publikationsdatum:
16. Oktober 2018 (online)

Abstract

Background Vascular occlusion after free flap surgery has become a rare complication but still poses a major challenge. It necessitates urgent re-exploration, but the logistic challenge to provide sufficient resources for the emergency intervention remains. The aim of this study was to analyze the long-term outcome after successful lower extremity free flap salvage.

Methods A single-center retrospective study including long-term follow-up was approved by the local ethics committee. From January 1999 to December 2010, a total of 581 free flaps were performed for lower extremity reconstruction. Eighty-six flaps required emergency re-exploration, of which 65 could be salvaged. Fifteen salvaged flaps were excluded from the study because of secondary amputation. Of 50 patients, 29 (6 females and 23 males) were eligible for follow-up. The mean follow-up time was 54.5 ± 32.9 months. Health-related quality of life (Short Form 36 [SF-36]) and scar quality (Vancouver Scar Scale [VSS]) were analyzed.

Results The overall flap survival rate was 94.7% and the total loss rate was 5.3%. The re-exploration rate was 14.8% (86 of 581 flaps). The salvage rate was 75.6% (65 of 86 flaps). Twenty-one free flaps were totally lost (24.4%). Partial flap loss occurred in 12 cases (14.0%); 67.5% of the vascular complications occurred during the first 24 hours, 20.9% between 24 and 72 hours, and 11.6% after more than 72 hours. The mean time from the first signs of impaired flap perfusion to re-exploration was 1.3 ± 0.4 hours, and from free tissue transfer to re-exploration was 16.2 ± 1.9 hours. The overall scar appearance was good with an average VSS score of 4.0 points. The average SF-36 physical component score was 54.4 ± 5.4 and the mental component score was 63.1 ± 10.7.

Conclusion Careful monitoring and the opportunity for urgent re-exploration are the key to success for free flaps salvage. Following these principles, an acceptable long-term outcome can be achieved.

 
  • References

  • 1 Shaw WW. Microvascular free flaps. The first decade. Clin Plast Surg 1983; 10 (01) 3-20
  • 2 Khouri RK, Cooley BC, Kunselman AR. , et al. A prospective study of microvascular free-flap surgery and outcome. Plast Reconstr Surg 1998; 102 (03) 711-721
  • 3 Pohlenz P, Blessmann M, Blake F, Li L, Schmelzle R, Heiland M. Outcome and complications of 540 microvascular free flaps: the Hamburg experience. Clin Oral Investig 2007; 11 (01) 89-92
  • 4 Hidalgo DA, Jones CS. The role of emergent exploration in free-tissue transfer: a review of 150 consecutive cases. Plast Reconstr Surg 1990; 86 (03) 492-498 , discussion 499–501
  • 5 Khouri RK. Free flap surgery. The second decade. Clin Plast Surg 1992; 19 (04) 757-761
  • 6 Kroll SS, Schusterman MA, Reece GP. , et al. Timing of pedicle thrombosis and flap loss after free-tissue transfer. Plast Reconstr Surg 1996; 98 (07) 1230-1233
  • 7 Kubo T, Yano K, Hosokawa K. Management of flaps with compromised venous outflow in head and neck microsurgical reconstruction. Microsurgery 2002; 22 (08) 391-395
  • 8 Salemark L. International survey of current microvascular practices in free tissue transfer and replantation surgery. Microsurgery 1991; 12 (04) 308-311
  • 9 Ho MW, Brown JS, Magennis P. , et al. Salvage outcomes of free tissue transfer in Liverpool: trends over 18 years (1992-2009). Br J Oral Maxillofac Surg 2012; 50 (01) 13-18
  • 10 Xiong L, Gazyakan E, Wähmann M. , et al. Microsurgical reconstruction for post-traumatic defects of lower leg in the elderly: a comparative study. Injury 2016; 47 (11) 2558-2564
  • 11 Xiong L, Gazyakan E, Kremer T. , et al. Free flaps for reconstruction of soft tissue defects in lower extremity: a meta-analysis on microsurgical outcome and safety. Microsurgery 2016; 36 (06) 511-524
  • 12 Disa JJ, Pusic AL, Hidalgo DH, Cordeiro PG. Simplifying microvascular head and neck reconstruction: a rational approach to donor site selection. Ann Plast Surg 2001; 47 (04) 385-389
  • 13 Culliford IV AT, Spector J, Blank A, Karp NS, Kasabian A, Levine JP. The fate of lower extremities with failed free flaps: a single institution's experience over 25 years. Ann Plast Surg 2007; 59 (01) 18-21 , discussion 21–22
  • 14 Panchapakesan V, Addison P, Beausang E, Lipa JE, Gilbert RW, Neligan PC. Role of thrombolysis in free-flap salvage. J Reconstr Microsurg 2003; 19 (08) 523-530
  • 15 Brown JS, Devine JC, Magennis P, Sillifant P, Rogers SN, Vaughan ED. Factors that influence the outcome of salvage in free tissue transfer. Br J Oral Maxillofac Surg 2003; 41 (01) 16-20
  • 16 Nakatsuka T, Harii K, Asato H. , et al. Analytic review of 2372 free flap transfers for head and neck reconstruction following cancer resection. J Reconstr Microsurg 2003; 19 (06) 363-368 , discussion 369
  • 17 Ware Jr JEJ, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992; 30 (06) 473-483
  • 18 Morfeld M, Bullinger M, Nantke J, Brähler E. The version 2.0 of the SF-36 Health Survey: results of a population-representative study [in German]. Soz Praventivmed 2005; 50 (05) 292-300
  • 19 Baryza MJ, Baryza GA. The Vancouver Scar Scale: an administration tool and its interrater reliability. J Burn Care Rehabil 1995; 16 (05) 535-538
  • 20 Sullivan T, Smith J, Kermode J, McIver E, Courtemanche DJ. Rating the burn scar. J Burn Care Rehabil 1990; 11 (03) 256-260
  • 21 Stranix JT, Lee ZH, Jacoby A. , et al. Forty years of lower extremity take-backs: flap type influences salvage outcomes. Plast Reconstr Surg 2018; 141 (05) 1282-1287
  • 22 DeFazio MV, Hung RW, Han KD, Bunting HA, Evans KK. Lower extremity flap salvage in thrombophilic patients: managing expectations in the setting of microvascular thrombosis. J Reconstr Microsurg 2016; 32 (06) 431-444
  • 23 Disa JJ, Hu QY, Hidalgo DA. Retrospective review of 400 consecutive free flap reconstructions for oncologic surgical defects. Ann Surg Oncol 1997; 4 (08) 663-669
  • 24 Bui DT, Cordeiro PG, Hu Q-Y, Disa JJ, Pusic A, Mehrara BJ. Free flap reexploration: indications, treatment, and outcomes in 1193 free flaps. Plast Reconstr Surg 2007; 119 (07) 2092-2100
  • 25 Hidalgo DA, Disa JJ, Cordeiro PG, Hu QY. A review of 716 consecutive free flaps for oncologic surgical defects: refinement in donor-site selection and technique. Plast Reconstr Surg 1998; 102 (03) 722-732 , discussion 733–734
  • 26 Pohlenz P, Klatt J, Schön G, Blessmann M, Li L, Schmelzle R. Microvascular free flaps in head and neck surgery: complications and outcome of 1000 flaps. Int J Oral Maxillofac Surg 2012; 41 (06) 739-743
  • 27 Henderson PW, Fernandez JG, Cemal Y. , et al. Successful salvage of late anastomotic thrombosis after free tissue transfer. J Reconstr Microsurg 2016; 32 (04) 316-324
  • 28 Weinzweig N, Gonzalez M. Free tissue failure is not an all-or-none phenomenon. Plast Reconstr Surg 1995; 96 (03) 648-660
  • 29 Wheatley MJ, Meltzer TR. The role of vascular pedicle thrombectomy in the management of compromised free tissue transfers. Ann Plast Surg 1996; 36 (04) 360-364
  • 30 Betancourt FM, Mah ET, McCabe SJ. Timing of critical thrombosis after replantation surgery of the digits. J Reconstr Microsurg 1998; 14 (05) 313-316