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Thromb Haemost 1997; 78(05): 1338-1342
DOI: 10.1055/s-0038-1665407
Review Article
Schattauer GmbH Stuttgart

Repeated Exercise Induces Release of Soluble P-Selectin in Patients with Intermittent Claudication

U J Kirkpatrick
The Department of Surgery, University Hospital of South Manchester, Manchester, UK
,
M Mossa
The Department of Surgery, University Hospital of South Manchester, Manchester, UK
,
A D Blann
The Department of Surgery, University Hospital of South Manchester, Manchester, UK
,
C N McCollum
The Department of Surgery, University Hospital of South Manchester, Manchester, UK
› Author Affiliations
Further Information

Publication History

Received 03 1997

Accepted after resubmission 20 June 1997

Publication Date:
12 July 2018 (online)

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Summary

Controversy exists as to whether exercise in patients with intermittent claudication causes a harmful biochemical effect associated with an ischaemia-reperfusion injury of skeletal muscle. We report on exercise-induced changes in neutrophil activation, soluble P-selectin and von Willebrand factor in 34 patients with intermittent claudication and 12 matched controls.

Von Willebrand factor (vWF) showed a cyclical pattern of response to exercise in control subjects (rising from 103 ± 8 to 119 ± 7 U/dl); claudicants did not show this pattern but had higher levels of vWF throughout (p <0.03). There was no consistent pattern of response in neutrophil hydrogen peroxide production to exercise in either claudicants or control subjects. Soluble P-selectin levels increased after exercise, but this only reached statistical significance after repeated exercise in claudicants (rising from 320 ± 28 to 357 ± 28 ng/ml). This rise in soluble P-selectin after exercise may indicate progressive platelet activation which may contribute to the excess cardiovascular mortality that claudicants are prone to.

 

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