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Thromb Haemost 1983; 50(04): 800-803
DOI: 10.1055/s-0038-1665316
Original Article
Schattauer GmbH Stuttgart

Haemostatic Variables and the Outcome of Myocardial Infarction

A P Haines
The MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, England
,
D Howarth
The MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, England
,
W R S North
The MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, England
,
Eva Goldenberg
The MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, England
,
Yvonne Stirling
The MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, England
,
T W Meade
The MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, England
,
E B Raftery
1   The Department of Cardiology, Northwick Park Hospital, Harrow, Middlesex, England
,
M W Millar Craig
1   The Department of Cardiology, Northwick Park Hospital, Harrow, Middlesex, England
› Author Affiliations
Further Information

Publication History

Received 20 June 1983

Accepted 22 August 1983

Publication Date:
18 July 2018 (online)

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Summary

In a study of 272 patients with myocardial infarction (MI) the 68 who died within 1 year had significantly higher levels of factor VIIIR:Ag, factor VIII:C, fibrinogen, α1 antitrypsin and α2 macroglobulin than those who survived. The mean white cell count (WCC) and peak creatine kinase (CK) were also significantly higher in those who died compared with the survivors. There was considerable intercorrelation between many of the haemostatic variables, WCC and CK as well as between many of the clinical predictors of outcome and the laboratory variables. The differences in haemostatic variables between those who died and those who survived may merely reflect the size of the infarct; alternatively, the haemostatic system may influence prognosis following an MI.

Keywords

Myocardial infarction - Prognosis - Coagulation
 

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