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Thromb Haemost 1983; 50(03): 669-670
DOI: 10.1055/s-0038-1665283
DOI: 10.1055/s-0038-1665283
Original Article
The Effect of Two Low Doses of Aspirin on Whole Blood Thromboxane and Prostacyclin Generation in Healthy Subjects
Further Information
Publication History
Received 21 February 1983
Accepted 13 July 1983
Publication Date:
18 July 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/198303/lookinside/thumbnails/10-1055-s-0038-1665283-1.jpg)
Summary
The effects of two low doses of aspirin (20 mg and 100 mg) on prostacyclin and thromboxane formation during whole blood clotting were studied in 8 healthy volunteers.
A single 100 mg aspirin dose caused more than 90% reduction of both serum TXB2 and 6-keto-PGF1α; a single 20 mg dose of aspirin inhibited serum TXB2 more than 6-keto-PGF1α but effects on these two products could not be completely dissociated.
However, the effect of a single 20 mg aspirin dose on serum TXB2, was of much longer duration than its inhibitory effect on PGI2 synthesis during whole blood clotting.
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