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Thromb Haemost 1986; 56(03): 293-294
DOI: 10.1055/s-0038-1661669
Original Article
Schattauer GmbH Stuttgart

Heparin-Induced Osteoporosis in Rats

Thomas Matzsch
*   The Department of General Surgery, University of Lund, Malmö General Hospital, Sweden
,
David Bergqvist
*   The Department of General Surgery, University of Lund, Malmö General Hospital, Sweden
,
Ulla Hedner
**   The Novo Research Institute, Copenhagen, Denmark
,
Bo Nilsson
***   The Department of Orthopedics, University of Lund, Malmö General Hospital, Sweden
,
Per Østergaard
**   The Novo Research Institute, Copenhagen, Denmark
› Author Affiliations
Further Information

Publication History

Received 23 June 1986

Accepted after revision 26 August 1986

Publication Date:
18 July 2018 (online)

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Summary

In order to study the effect of heparin in inducing osteoporosis, 30 female rats were divided in two groups and treated with daily injections of 2 IU heparin/g body weight for 33 and 65 days and compared with the same number of rats acting as controls. The mineral bone mass in the femora of the animals was measured quantitatively. A significant (p <0.001) reduction in bone mineral mass was found in the heparin-treated animals. This effect was present to the same degree after 33 days as after 65 days of treatment. It is concluded that heparin in this dose causes osteoporosis in rats after 33 days and that the described method can be used as an experimental model for further studies on this topic.

Keywords

Heparin - Osteoporosis
 

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