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Thromb Haemost 1986; 55(03): 325-329
DOI: 10.1055/s-0038-1661556
Original Article
Schattauer GmbH Stuttgart

Blood Platelet Plasminogen Activator Inhibitor: Two Different Pools of Endothelial Cell Type Plasminogen Activator Inhibitor in Human Blood

E D Sprengers
1   The TNO Gaubius Institute for Cardiovascular Research, Leiden, The Netherlands
,
J W N Akkerman
2   The Department of Haematology, University Hospital Utrecht, Utrecht, The Netherlands
,
B G Jansen
1   The TNO Gaubius Institute for Cardiovascular Research, Leiden, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 06 December 1985

Accepted after revision 07 March 1986

Publication Date:
18 July 2018 (online)

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Summary

An assay for plasminogen activator inhibitor in human platelets is described. With this assay we find an average value of 6.8 × 10−8 IU/platelet (S.D. = 3.0 × 10−8; n = 20) in a healthy population. We characterized the PA-inhibitor from platelets and identified it as endothelial cell type plasminogen activator inhibitor, by its immunologic and functional properties. Besides the plasma pool of plasminogen activator inhibitor with a very high turnover rate, platelets constitute a second pool of plasminogen activator inhibitor in the circulation of the same order of magnitude. The two different pools of plasminogen activator inhibitor might have a different physiologic function.

Keywords

Fibrinolysis - Platelets - Plasminogen activator inhibitor Summary
 

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