PDF herunterladen
Thromb Haemost 1984; 51(03): 362-365
DOI: 10.1055/s-0038-1661102
Original Article
Schattauer GmbH Stuttgart

Blood Changes and Enhanced Thromboxane and 6-Keto Prostaglandin F1α Production in Experimental Acute Plasmodium Bergei Infection in Hamsters

E M Essien
*   The Department of Haematology, University of Ibadan, Nigeria
,
J Arnout
The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Belgium
,
H Deckmyn
The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Belgium
,
J Vermylen
The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Belgium
,
M Verstraete
The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Belgium
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 12. Dezember 1982

Accepted 05. April 1984

Publikationsdatum:
19. Juli 2018 (online)

Auch verfügbar auf
  als PDF herunterladen  Lizenzen und Reprints

Summary

Golden hamsters inoculated intraperitoneally with Plasmodium bergei infected mouse blood regularly developed P. bergei parasitaemia. This was associated with progressive thrombocytopenia and leucocytosis as the degree of parasitaemia increased with time. When infected whole blood was stimulated with collagen, significantly enhanced thromboxane B2 (TXB2) production per platelet was seen. 6-keto prostaglandin (PG) F1α formation in the same system increased from the sixth infection day onwards and correlated with the relative leukocytosis. The production of 6-keto PGF1α by aorta rings was significantly higher during the 4-7th days postinoculation. The increase in thromboxane production however was much more important than that of 6-keto PGF1α and it therefore is concluded that P. bergei parasitaemia in hamsters tilts the haemostatic balance towards the platelet hyperaggregability that has also been described in P. falciparum infection in man.

Keywords

P. bergei parasitaemia - Platelets - Thromboxane - Prostacyclin - Whole blood
 

  • References

  • 1 Knüttgen H. Knochenmarksbefunde bei malaria tertiana. Z Tropenmed Parasitol 1949; 1: 178-194
    PubMedGoogle Scholar
  • 2 Hill GJ, Knight V, Jeffery GM. Thrombocytopenia in vivax malaria. Lancet 1964; 1: 240-241
    PubMedGoogle Scholar
  • 3 Skudowitz RB, Katz J, Lurie A, Levin J, Metz J. Mechanisms of thrombocytopenia in malignant tertian malaria. Br Med J 1973; 2: 515-517
    CrossrefPubMedGoogle Scholar
  • 4 Essien EM, Oruamabo RS. Depression of platelet count during acute falciparum malaria infection. Niger J Paediatr 1976; 3: 69-70
    PubMedGoogle Scholar
  • 5 Essien EM, Adekunle CO, Ebhota MI, Oruamabo RS. Effect of acute plasmodium falciparum infection on platelet count in man. Niger J Med Sei 1979; 1: 59-63
    PubMedGoogle Scholar
  • 6 Horstman RD, Dietrich M, Bienzle U, Rasche H. Malaria-induced thrombocytopenia. Blut 1981; 42: 157-164
    CrossrefPubMedGoogle Scholar
  • 7 Borochovitz D, Crosley AL, Metz J. Disseminated intravascular coagulation with fatal haemorrhage in cerebral malaria. Br Med J 1970; 2: 710-712
    CrossrefPubMedGoogle Scholar
  • 8 Srichaikul T, Puwasatien P, Karnjanajetanee J, Bokish VA. Complement changes and disseminated intravascular coagulation in plasmodium falciparum malaria. Lancet 1975; 1: 770-772
    PubMedGoogle Scholar
  • 9 Fajardo LF, Tallent C. Malaria parasites within human platelets. J Am Med Assoc 1974; 229: 1205-1207
    CrossrefPubMedGoogle Scholar
  • 10 Kelton JG, Keystone J, Moore J, Denomme G, Tozman E, Glynn M, Neame PB, Gauldie J, Jensen J. Immune-mediated thrombocytopenia of malaria. J Clin Invest 1983; 71: 832-836
    CrossrefPubMedGoogle Scholar
  • 11 Essien EM, Ebhota MI. Platelet hypersensitivity in acute malaria plasmodium falciparum infection in man. Thromb Haemostas 1981; 46: 547-549
    PubMedGoogle Scholar
  • 12 Ludlam CA, Moore S, Bolton AE, Pepper DS, Cash JD. The release of a human platelet-specific protein measured by a radioimmunoassay. Thromb Res 1975; 6: 543-548
    CrossrefPubMedGoogle Scholar
  • 13 Kaplan BS, Fong JS. Platelet aggregation in haemolytic uraemic syndrome. Lancet 1980; 1: 46
    PubMedGoogle Scholar
  • 14 Hamberg M, Svensson J, Samuelsson B. Novel transformations of prostaglandin endoperoxides: formation of thromboxanes. Adv Prostaglandin Thromboxane Res 1976; 1: 19-27
    PubMedGoogle Scholar
  • 15 Moncada S, Vane JR. Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2 and prostacyclin. Pharmacol Rev 1979; 30: 293-329
    PubMedGoogle Scholar
  • 16 Defreyn G, Deckmyn H, Vermylen J. A thromboxane synthetase inhibitor reorients endoperoxide metabolism in whole blood towards prostacyclin and prostaglandin E2 . Thromb Res 1982; 26: 389-400
    CrossrefPubMedGoogle Scholar
  • 17 Carreras LO, Chamone DA F, Klerckx P, Vermylen J. Decreased vascular prostacyclin (PGI2) in diabetic rats. Stimulation of PGI2 release in normal and diabetic rats by the antithrombotic compound Bay g 6575 Thromb Res 1980; 19: 663-670
    CrossrefPubMedGoogle Scholar
  • 18 Cox FE. Concomitant infections. In: Rodent Malaria. Killic-Kendrick R, Peters W. (eds) pp 309-343 Academic Press; London: 1978
    Google Scholar
  • 19 Goldstein IM, Malmsten CL, Kindahl H, Kaplan HB, Rädmark O, Samuelsson B, Weissmann G. Thromboxane generation by human peripheral blood polymorphonuclear leukocytes. J Exp Med 1978; 148: 787-792
    CrossrefPubMedGoogle Scholar
  • 20 Gordon D, Nouri AM I, Thomas RU. Selective inhibition of thromboxane synthesis in human blood mononuclear cells and the effects on mitogen-stimulated lymphocyte proliferation. Br J Pharmacol 1981; 74: 469-475
    CrossrefPubMedGoogle Scholar
  • 21 Salmon JA. Inhibition of arachidonic acid metabolism. In: Cardiovascular Pharmacology of the Prostaglandins. Herman AG, Vanhoutte PM, Denolin H, Goossens A. (eds) pp 7-22 Raven Press; New York: 1982
    Google Scholar
  • 22 Parry MJ, Randall MJ, Tyler HM, Myhre E, Dale J, Thaulow E. Selective inhibition of thromboxane synthetase by dazoxiben increases prostacyclin production by leukocytes in angina patients and healthy volunteers. Lancet 1982; 1: 164
    PubMedGoogle Scholar
  • 23 Weston MJ, Jackman N, Rudge C, Bowles J, Brady C, Bielawska C, O’Grady J. Prostacyclin in falciparum malaria. Lancet 1982; 2: 609
    PubMedGoogle Scholar