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DOI: 10.1055/s-0038-1661095
Plasmin Inhibitors and Fibrinogen Breakdown During the Initial Phase of Thrombolytic Treatment - The Problem of the α2-Antiplasmin Determination
Publikationsverlauf
Received 26. Januar 1984
Accepted 19. März 1984
Publikationsdatum:
19. Juli 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/198403/lookinside/thumbnails/10-1055-s-0038-1661095-1.jpg)
Summary
During the first 3 hr of thrombolytic treatment with porcine plasmin (p-PL) or streptokinase (SK) a rapid decrease of clottable fibrinogen with generation of large amounts of fibrin(-ogen) degradation products (FDP) are found. α2-antiplasmin (α2AP) is rapidly neutralized. Whereas in patients treated with SK more than half of the original plasminogen was consumed, its level remained unchanged during p-PL infusion. When α2AP reaches values below some 20%, spontaneous amidolytic activity towards S-2251 representing either PL-α2-macroglobulin- or SK-plasminogen-complex activity appears. This activity has to be considered in the α2AP assay in order to avoid underestimation of this inhibitor.
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