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Thromb Haemost 1985; 54(03): 661-664
DOI: 10.1055/s-0038-1660092
DOI: 10.1055/s-0038-1660092
Original Article
Hepatic Clearance of Tissue-Type Plasminogen Activator in Rats
Weitere Informationen
Publikationsverlauf
Received 26. April 1985
Accepted 31. Juli 1985
Publikationsdatum:
19. Juli 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/198503/lookinside/thumbnails/10-1055-s-0038-1660092-1.jpg)
Summary
The clearance of tissue-type plasminogen activator (t-PA) was studied, in rats, by use of a functional assay for t-PA. Half-lives in the circulation were about one minute both for human (melanoma cell-derived) t-PA and for the rat’s own t-PA. The clearance of t-PA required an intact liver blood flow. In isolated liver perfusion experiments the hepatic extraction of t-PA did not require any plasma proteins, including fast-acting t-PA inhibitor. Competition experiments, using monosaccharides, suggested that known hepatic glycoprotein receptors were not involved in hepatic t-PA extraction.
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