Download PDF
Hamostaseologie 1988; 08(01): 1-7
DOI: 10.1055/s-0038-1659942
Originalarbeiten
Schattauer GmbH

Einfluß von Antibiotika auf das plasmatische und thrombozytäre Gerinnungssystem

A. Haubenstock
1   Aus der L Medizinischen Universitätsklinik Wien (Vorstand: Prof. Dr. Dr. h. c. E. Deutsch)
,
A. Kiss
1   Aus der L Medizinischen Universitätsklinik Wien (Vorstand: Prof. Dr. Dr. h. c. E. Deutsch)
,
W. Base
1   Aus der L Medizinischen Universitätsklinik Wien (Vorstand: Prof. Dr. Dr. h. c. E. Deutsch)
› Author Affiliations
Further Information

Publication History

Publication Date:
25 June 2018 (online)

Also available at
    Permissions and Reprints

 

 

  • Literatur

  • 1 Aggeier P.M, O’Reilly R.A. Effect of heptabarbital on the response to bishydro-xycournarin in man. J Lab Clin Med 1969; 74: 229-38.
    PubMedGoogle Scholar
  • 2 Agnelli G, Del Favero A, Parise P. et al. Cephalosporin-induced hypoprothrombin-einia: is the N-methylthiotetrazole side chain the culprit?. Antimicrob Agents Chemother 1986; 29: 1108-9.
    CrossrefPubMedGoogle Scholar
  • 3 Alexander D.P, Russo M.E, Fohrman D.E, Rothstein G. Nafcillin-induced platelet dysfunction and bleeding. Antimicrob Agents Chemother 1983; 23: 59-62.
    CrossrefPubMedGoogle Scholar
  • 4 Andrassy K, Weisenedel E, Ritz E, Andrassy T. Bleeding in uremic patients after carbenicillin. Thromb Haemost 1976; 36: 115-26.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Aronoff G.R, Wolen R.L, Obermeyer B.D, Black H.R. Pharmacokinetics and protein binding of cefamandole and its 1-methy 1-5-thiol side chain in subjects with normal and impaired renal function. J Infect Dis 1986; 153: 1069-74.
    CrossrefPubMedGoogle Scholar
  • 6 Ballard J.O, Barnes S.G, Sattler F.R. Comparison of the effects of mezlocillin, carbenicillin, and placebo on normal nemo-stasis. Antimicrob Agents Chemother 1984; 25: 153-6.
    CrossrefPubMedGoogle Scholar
  • 7 Barza M, Furie B, Brown A.E, Furie B.C. Defects in vitamin K dependent carboxylation associated with moxalactam treatment. J Infect Dis 1986; 153: 1166-9.
    CrossrefPubMedGoogle Scholar
  • 8 Baxter J.G, Marble D.A, Whitfield L.R, Wels P.B, Walczak P, Schentag J.J. Clinical risk factors for prolonged PT/PTT in abdominal sepsis patients treated with moxalactam or tobramycin plus clindamycin. Ann Surg 1985; 201: 96-102.
    PubMedGoogle Scholar
  • 9 Bechtold H, Andrassy K, Jahnchen E. et al. Evidence for impaired hepatic vitamin K, metabolism in patients treated with N-me-thyl-thiotetrazole cephalosporins. Thromb Haemost 1984; 51: 358-61.
    PubMedGoogle Scholar
  • 10 Black H.R, Buening M.K, Wolen R.L. Latamoxef, its side chain, and coagulation. Lancet 1983; 11: 1090.
    PubMedGoogle Scholar
  • 11 Boyd D.B, Lunn W.H. Electronic structures of cephalosporins and penicillins: 9. Departure of a leaving group in cephalosporins. J Med Chem 1979; 22: 778-84.
    CrossrefPubMedGoogle Scholar
  • 12 Breckenridge A.M. Interindividual differences in the response to oral anticoagulants. Drugs 1977; 14: 367-75.
    CrossrefPubMedGoogle Scholar
  • 13 Brown III C.H, Natelson E.A, Bradshaw W, Williams Jr T.W, Alfrey Jr C.P. The hemostatic defect produced by carbenicillin. N Engl J Med 1974; 291: 265-70.
    CrossrefPubMedGoogle Scholar
  • 14 Brown III C.H, Natelson E.A, Bradshaw M.W, Alfrey Jr C.P, Williams Jr T.W. Study of the effects of ticarcillin on blood coagulation and platelet function. Antimicrob Agents Chemother 1975; 7: 652-7.
    CrossrefPubMedGoogle Scholar
  • 15 Cohen M.S, Washton H.E, Barranco S.F. Multicenter clinical trial of cefoperazon sodium in the United States. Am J Med 1984; 77 1B 35-41.
    PubMedGoogle Scholar
  • 16 Di Minno G, Martinez J, McKcan M.L, De La Rosa J, Burke J.F, Murphy S. Platelet dysfunction in uremia: multifacted defect partially corrected by dialysis. Am J Med 1985; 79: 552-9.
    CrossrefPubMedGoogle Scholar
  • 17 Fainstein V, Bodey G.P, McCredie K.B. et al. Coagulation abnormalities induced by be ta-lactam antibiotics in cancer patients. J Infect Dis 1983; 148: 745-7.
    CrossrefPubMedGoogle Scholar
  • 18 Fass R.J, Copelan E.A, Brandt J.T, Moeschberger M.L, Ashton J.J. Platelet-mediated bleeding caused by broad-spectrum penicillins. J I n feet Dis 1987; 155: 1242-8.
    PubMedGoogle Scholar
  • 19 Frick P.G, Riedler G, Brogli H. Dose response and minimal daily requirement for vitamin K in man. J Appl Physiol 1967; 23: 387-9.
    CrossrefPubMedGoogle Scholar
  • 20 Friedman P.A. Vitamin K dependent proteins. N Engl J Med 1984; 310: 1458-60.
    CrossrefPubMedGoogle Scholar
  • 21 Gentry L.O, Jemsek J.G, Natelson E.A. Effects of sodium piperacillin on platelet function in normal volunteers. Antimicrob Agents Chemother 1981; 19: 532-3.
    CrossrefPubMedGoogle Scholar
  • 22 Gentry L.O, Wood B.A, Natelson E.A. Effects of apalcillin on platelet function in normal volunteers. Antimicrob Agents Chemother 1985; 27: 683-4.
    CrossrefPubMedGoogle Scholar
  • 23 Habiirchak D.R, Head D.R, Everett E.D. Postoperative hemorrhage associated with carbenicillin administration: report of two cases and review of the literature. Am J Surg 1977; 134: 630-4.
    CrossrefPubMedGoogle Scholar
  • 24 Ham J.M. Hypoprothrombinaemia in patients undergoing prolonged intensive care. Med J Aust 1971; 2: 716-8.
    PubMedGoogle Scholar
  • 25 Haubenstock A, Schmidt P, Zazgornik J, Balcke P, Kopsa H. Hypoprothrombin-aemic bleeding associated with ceftriaxone. Lancet 1983; I: 1215-6.
    PubMedGoogle Scholar
  • 26 Heinrich D. Häufigkeit, Diagnostik und Therapie medikamentös induzierter Blutungen. Hämostaseologie 1987; 7: 44-52.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 27 Hooper C.A, Haney B.B, Stone H.H. Gastrointestinal bleeding due to vitamin K deficiency in patients on parenteral cefamandole. Lancet 1980; I: 39-40.
    PubMedGoogle Scholar
  • 28 Joehl R.J, Rasbach D.A, Ballard J.O, Weitekamp M.R, Sattler F.R. Moxalactam: evaluation of clinical bleeding in patients with abnormal infection. Arch Surg 1983; 118: 1259-61.
    CrossrefPubMedGoogle Scholar
  • 29 Kelton J.G, Metzler D, Moore J. Drug-induced thrombocytopenia is associated with increased binding of IgG to platelets both in vivo and in vitro. Blood 1981; 58: 524-7.
    PubMedGoogle Scholar
  • 30 Klippel A.P, Pitsinger B. Hypoprothrom-binaemia secondary to antibiotic therapy and manifested by massive gastrointestinal hemorrhage: report of three cases. Arch Surg 1968; 96: 266-8.
    CrossrefPubMedGoogle Scholar
  • 31 Lipsky J.J. N-mcthyl-thio-tetrazole inhibition of the gamma carboxylation of glutamic acid: possible mechanism for antibiotic-associated hypoprothrombinaemia. Lancet 1983; II: 192-3.
    PubMedGoogle Scholar
  • 32 Lipsky J.J. Mechanism of the inhibition of the gamma-carboxylation of glutamic acid by N-methylthiotetrazole-containing antibiotics. Proc Natl Acad Sci USA 1984; 81: 2893-7.
    CrossrefPubMedGoogle Scholar
  • 33 Lipsky J.J, Lewis J.C, Novick Jr W.H. Production of hypoprothrombinemia by moxalactam and 1-methyl-5-thiotetrazole in rats. Antimicrob Agents Chemother 1984; 25: 380-1.
    CrossrefPubMedGoogle Scholar
  • 34 Lipsky J.J, Lewis J.C, Novick W.J. The role of the 2-methyl,l,3,4-thiadiazole-S-thiol leaving group in cefazolin-induced hypoprothrombinemia [Abstract 703]. In : Program and Abstracts - 25th Interscience Conference on Antimicrobial Agents and Chemotherapy, Minneapolis, Minnesota. Washington, D. C.: American Society for Microbiology; 1985.
    PubMedGoogle Scholar
  • 35 Lurie A, Ogilvie M, Townsend R, Gold C, Meyers A.M, Goldberg B. Carbenicillin-induced coagulopathy. Lancet 1970; I: 1114-5.
    PubMedGoogle Scholar
  • 36 McClure P.D, Casserly J.G, Monsier C, Crozier D. Carbenicillin-indueed bleeding disorder. Lancet 1970; II: 1307-8.
    PubMedGoogle Scholar
  • 37 O’Reilly R.A. Interaction of chronic daily warfarin therapy and rifampin. Ann Intern Med 1975; 83: 506-8.
    CrossrefPubMedGoogle Scholar
  • 38 Padfield J.M, Kellaway I.W. Rheological studies on mixed phospholipid sols and their interaction with penicillins: I. Continuous shear viscometry. Chem Phys Lipids 1973; 10: 356-68.
    CrossrefPubMedGoogle Scholar
  • 39 Pineo G.F, Gallus A.S, Hirsh J. Unexpected vitamin K deficiency in hospitalized patients. Can Med Assoc J 1973; 109: 880-3.
    PubMedGoogle Scholar
  • 40 Quershi G.D, Reinders T.P, Somori G.J, Evans H.J. Warfarin resistance with nafcil-lin therapy. Ann Intern Med 1984; 100: 527-9.
    CrossrefPubMedGoogle Scholar
  • 41 Reddy J, Bailey R.R. Vitamin K deficiency developing in patients with renal failure treated with cephalosporin antibiotics. NZ Med J 1980; 92: 378-9.
    PubMedGoogle Scholar
  • 42 Romotar K, Conly J.M, Chubb H, Louie T.J. Production of menaquinones by intestinal anaerobes. J Infect Dis 1984; 150: 213-8.
    CrossrefPubMedGoogle Scholar
  • 43 Sattler F.R, Colao D.J, Caputo G.M, Schoolwerth A.C. Cefoperazone for empiric therapy in patients with impaired renal function. Am J Med 1986; 81: 229-36.
    CrossrefPubMedGoogle Scholar
  • 44 Sattler F.R, Weitekamp M.R, Ballard J.O. Potential for bleeding with the new beta-lactam antibiotics. Ann Intern Med 1986; 105: 924-31.
    CrossrefPubMedGoogle Scholar
  • 45 Shattil S.J, Bennett J.S, McDonough M, Turnbull J. Carbenicillin and penicillin G inhibit platelet function in vitro by impairing the interaction of agonists with the platelet surface. J Clin Invest 1980; 65: 329-37.
    CrossrefPubMedGoogle Scholar
  • 46 Somani P, Smith M.R, Gohara A, Kapila K. The effects of mezlocillin, ticarcillin and placebo on blood coagulation and bleeding time in normal volunteers. J Antimicrob Chemother 1983; 11 suppl C 33-41.
    PubMedGoogle Scholar
  • 47 Uotila L, Suttie J.W. Inhibition of vitamin K-dependent carboxylase in vitro by cefa-mandole and its structural analogs. J Infect Dis 1983; 148: 571-8.
    CrossrefPubMedGoogle Scholar
  • 48 Wackett T, Kelton J.G, Powers P. Drug-induced platelet destruction. Semin Thromb Hemostas 1982; 8: 116-25.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 49 Weitekamp M.R, Aber R.C. Prolonged bleeding times and bleeding diathesis associated with moxalactam administration. JAMA 1983; 249: 69-71.
    CrossrefPubMedGoogle Scholar
  • 50 Weitekamp M.R, Caputo G.M, Al-Mondhiry H.A, Aber R.C. The effects of latamoxef, cefotaxime, and cefoperazone on platelet function and coagulation in normal volunteers. J Antimicrob Chemother 1985; 16: 95-101.
    CrossrefPubMedGoogle Scholar
  • 51 Wikler M, Lentek A, McDevitt J, Hoscutt J, Nichols R. Evaluation of hypoprothrom-binemia (HP) in patients treated with third generation cephalosporins. [Abstract 961]. In: Program and Abstracts - 24th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington D.C.: American Society for Microbiology:; 1984
    Google Scholar