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Thromb Haemost 1997; 78(03): 1003-1007
DOI: 10.1055/s-0038-1657677
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Schattauer GmbH Stuttgart

Variable Platelet Response to Low-dose ASA and the Risk of Limb Deterioration in Patients Submitted to Peripheral Arterial Angioplasty

Michael Rolf Mueller
1   The University of Vienna, Department of Cardio-Thoracic Surgery, Vienna, Austria
,
Andreas Salat
2   The University of Vienna, Department of General Surgery, Vienna, Austria
,
Petra Stangl
2   The University of Vienna, Department of General Surgery, Vienna, Austria
,
Marco Murabito
3   The University of Vienna, Department of Center f. Biomedical Research and LBI f. Cardio-Surgical Research, Vienna, Austria
,
Sad Pulaki
3   The University of Vienna, Department of Center f. Biomedical Research and LBI f. Cardio-Surgical Research, Vienna, Austria
,
Dagmar Boehm
4   The University of Vienna, Department of Clinic of Anesthesiology and General Intensive Care Medicine, Vienna, Austria
,
Renate Koppensteiner
5   The University of Vienna, Department of Angiology, Vienna, Austria
,
Erdem Ergun
6   The University of Vienna, Department of Clinic of Ophtalmology, Vienna, Austria
,
Martina Mittlboeck
7   The University of Vienna, Institute of Medical Computer Science, Vienna, Austria
,
Wolfgang Schreiner
7   The University of Vienna, Institute of Medical Computer Science, Vienna, Austria
,
Udo Losert
3   The University of Vienna, Department of Center f. Biomedical Research and LBI f. Cardio-Surgical Research, Vienna, Austria
,
Ernst Wolner
1   The University of Vienna, Department of Cardio-Thoracic Surgery, Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received 10 1997

Accepted after resubmission 13 May 1997

Publication Date:
12 July 2018 (online)

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Summary

A group of 100 patients with intermittent claudication (70 male, 30 female), treated with 100 mg ASA per day, were followed over 18 months after elective percutaneous balloon angioplasty. Platelet function was monitored over a period of 12 months by corrected whole blood aggregometry (CWBA). Upon stimulation by arachidonic acid (AA), adenosine diphosphate (ADP) and collagen, CWBA-results were obtained by an electronic acquisition and evaluation system correcting for hematocrit and platelet count of the blood sample.

All patients showed a completely inhibited platelet response to AA stimulation. Comparison of the CWB A-results with clinical parameters revealed that reocclusions at the site of angioplasty occurred exclusively in male patients for which CWBA failed to prove an inhibition of aggregation upon both agonists, ADP and collagen, and for these patients the risk of complication is at least 87% higher (p = 0.0093).

Only 40% of male patients show the expected effect of ASA on in vitro platelet aggregation at any given point in time and CWBA is capable of predicting those male patients which are at an elevated risk of reocclusion following peripheral angioplasty.

 

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