Download PDF
Thromb Haemost 1997; 78(01): 310-314
DOI: 10.1055/s-0038-1657545
Leukocyte-endothelial cell interactions
Schattauer GmbH Stuttgart

The Role of Leukocyte and Endothelial Adhesion Molecules in Ischemia – Reperfusion Injury

Ravi R Thiagarajan
1   Department of Anesthesia & Critical Care, University of Washington, Children’s Hospital & Medical Center, Seattle, WA, USA
,
Robert K Winn
2   Department of Surgery, Department of Physiology and Biophysics, Harborview Medical Center, University of Washington, Seattle, WA, USA
,
John M Harlan
3   Department of Medicine, Division of Hematology, University of Washington Seattle, WA, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
12 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints
 

  • References

  • 1 Cornejo CJ, Winn RK, Harlan JM. Anti-Adhesion Therapy. Advances in Pharmacology. 1997 (in press)
    PubMedGoogle Scholar
  • 2 Parks DA, Bulkley GB, Granger DN, Hamilton SR, McCord MJ. Ischemic injury in the cat small intestine: role of superoxide radicals. Gastroenterology 1982; 82 (01) 09-15
    PubMedGoogle Scholar
  • 3 Harlan JM, Winn RK, Doerschuk CM, Vedder NB, Rice CL. In vivo models of leukocyte adherence to endothelium. In Adhesion: Its Role in Inflammatory Disease. Harlan JM, Liu D. eds. W.H Freeman & Co; New York: 1992. pp 117-150
    Google Scholar
  • 4 Gute D, Korthuis RJ. Role of Leukocyte Adherence in Reperfusion-Induced Microvascular Dysfunction and Tissue Injury. In Physiology and Pathophysiology of Leukocyte Adhesion. Granger DNaGWS-S. ed. Oxford Press; New York: 1995. pp 359-380
    Google Scholar
  • 5 Winn RK, Sharar SR, Vedder NV, Harlan JM. The Contribution of Adherent Leukocytes to Circulatory Shock. In Physiology and Pathophysiology of Leukocyte Adhesion. Schmid-Schonbein DNGaGW. ed. Oxford University Press; New York: 1995. pp 381-392
    Google Scholar
  • 6 Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994; 84: 2068-2101
    PubMedGoogle Scholar
  • 7 Schmid-Schonbein GW. Capillary plugging by granulocytes and the no reflow phenomenon in the microvasculature. FASEB J 1987; 46: 2397-2401
    PubMedGoogle Scholar
  • 8 Hernandez LA, Grisham MB, Twohig B, Arfors K-E, Harlan JM, Granger DN. Role of neutrophils in ischemia-reperfusion induced microvascular injury. Am.J. Physiol 1987; 253: H699-H703
    PubMedGoogle Scholar
  • 9 Rabb H, Ramitez G, Saba SR, Reynolds D, Xu J, Flavell R, Antonia S. Renal ischemic-reperfusion injury in L-selectin deficient mice. Am. J. Physiol 1996; 271: F408-F413
    PubMedGoogle Scholar
  • 10 Weight SC, Bell PR, Nicholson ML. Renal ischaemia-reperfusion injury. Br J Surg 1996; 83 (02) 162-170
    CrossrefPubMedGoogle Scholar
  • 11 Seekamp A, Till GO, Mulligan MS, Paulson JC, Anderson DC, Miyasak M, Ward PA. Role of selectins in local and remote tissue injury following ischemia and reperfusion. Am J Pathol 1994; 144: 592-598
    PubMedGoogle Scholar
  • 12 Altavilla D, Squadrito F, Ioculano M, Canale P, Campo GM, Zingarelli B, Caputi AP. E-selectin in the pathogenesis of experimental myocardial ischemia-reperfusion injury. Eur J Pharmacol 1994; 270: 45-51
    PubMedGoogle Scholar
  • 13 Haring HP, Berg EL, Tsurushita N, Tagay M, del GJ. E-selectin appears in nonischemic tissue during experimental focal cerebral ischemia. Stroke 1996; 27 (08) 1386-1391 discussion 1391-1382
    CrossrefPubMedGoogle Scholar
  • 14 Moore TM, Khimenko P, Miyasako M, Taylor AE. Adhesion molecules contribute to ischemia and reperfusioninduced injury in the isolated rat lung. J Appl Physiol 1995; 78: 2245-2252
    CrossrefPubMedGoogle Scholar
  • 15 Winn RK, Liggitt D, Vedder NB, Paulson JC, Harlan JM. Anti-P-selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear. J. Clin. Invest 1993; 92: 2042-2047
    CrossrefPubMedGoogle Scholar
  • 16 Mihelcic D, Schleiffenbauffi B, Tedder TF, Sharar SR, Harlan Winn, Winn RK. Inhibition of leukocyte L-selectin function with a monoclonal antibody attenuates reperfusion injury to the rabbit ear. Blood 1994; 84: 2322-2328
    PubMedGoogle Scholar
  • 17 Kubes P, Jutila M, Payne D. Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion. J Clin Invest 1995; 95 (06) 2510-2519
    CrossrefPubMedGoogle Scholar
  • 18 Picker LJ, Warnock RA, Burns AR, Doerschuk CM, Berg EL, Butcher EC. The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Cell 1991; 66: 921-933
    CrossrefPubMedGoogle Scholar
  • 19 Garcia NM, Mileski WJ, Sikes P, AtileS L, Lightfoot E, Lipsky P, Baxter C. Effect of inhibiting leukocyte integrin (CD 18) and selectin (L-selectin) on susceptibility to infection with Pseudomonas aeruginosa. J Trauma 1994; 36: 714-718
    CrossrefPubMedGoogle Scholar
  • 20 Gibbs SA, Weiser MR, Kobzik L, Valer CR, Shepro D, Hechtman HB. P-selectin mediates intestinal ischemic injury by enhancing complement deposition. Surgery 1996; 119: 652-656
    CrossrefPubMedGoogle Scholar
  • 21 Kurose I, Anderson DC, Miyasaka M, Tamatani T, Paulson JC, Todd RF, Rusche JR, Granger DN. Molecular determinants of reperfusion-induced leukocyte adhesion and vascular protein leakage. Circ Res 1994; 74: 336-343
    CrossrefPubMedGoogle Scholar
  • 22 Doerschuk CM. The role of CD18-mediated adhesion in neutrophil sequestration induced by infusion of activated plasma in rabbits. Am J Respir Cell Mol Biol 1992; 7: 140-148
    CrossrefPubMedGoogle Scholar
  • 23 von Andrian UH, Berger EM, Ramezani L, Chambers JD, Ochs HD, Harlan JM, Paulson JC, Etzioni A, Arfors KE. In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes. J Clin Invest 1993; 91: 2893-2897
    CrossrefPubMedGoogle Scholar
  • 24 Ma X-L, Tsao PS, Lefer AM. Antibody to CD 18 exerts endothelial and cardiac protective effects inmyocardial ischemia and reperfusion. J. Clin. Invest 1991; 88: 1237-1243
    CrossrefPubMedGoogle Scholar
  • 25 Mori E, del ZoppoG J, Chambers JD, Copeland BR, Arfors KE. Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons. Stroke 1992; 23: 712-718
    CrossrefPubMedGoogle Scholar
  • 26 Connolly Jr E, Winfree CJ, Springer TA, Naka Y, Liao H, Yan SD, Stern DM, Solomon RA, Gutierrez-Ramos JC, Pinsky DJ. Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke. J Clin Invest 1996; 97: 209-216
    CrossrefPubMedGoogle Scholar
  • 27 Murohara T, Delyani JA, Albelda SM, Lefer AM. Blockade of platelet endothelial cell adhesion molecule-1 protects against myocardial ischemia and reperfusion injury in cats. J Immunol 1996; 156: 3550-3557
    PubMedGoogle Scholar
  • 28 Vedder NB, Winn RK, Rice CL, Chi E, Arfors K-E, Harlan JM. Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuates reperfusion injury in the rabbit ear. Proc. Natl. Acad. Sci 1990; 81: 939-944
    PubMedGoogle Scholar
  • 29 Sharar SR, Mihelcic DD, Han KT, Harlan JM, Winn RK. Ischemia-reperfusion injury in the rabbit ear is reduced by both immediate and delayed CD 18 leukocyte adherence blockade. J. Immunol 1994; 153: 2234-2238
    PubMedGoogle Scholar
  • 30 Han KT, Sharar SR, Phillips ML, Harlan JM, Winn RK. Sialyl Lewis(x) oligosaccharide reduces ischemia-reperfusion injury in the rabbit ear. J Immunol 1995; 155: 4011-4015
    PubMedGoogle Scholar
  • 31 Vedder NB, Winn RK, Rice CL, Chi E, Arfors K-E, Harlan JM. A monoclonal antibody to the adherence promoting leukocyte glycoprotein CD 18 reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits. J. Clin. Invest 1988; 81: 939-944
    CrossrefPubMedGoogle Scholar
  • 32 Vedder NB, Fouty BW, Winn RK, Harlan JM, Rice CL. Role of neutrophils in generalized reperfusion injury associated with resuscitation from shock. Surgery 1989; 106: 509-516
    PubMedGoogle Scholar
  • 33 Mileski WJ, Winn RK, Vedder NV, Pohlman TH, Harlan JM, Rice CL. Inhibition of CD 18-dependent neutrophil adherence reduces organ injury after hemorrhagic shock in primates. Surgery 1990; 108: 205-212
    PubMedGoogle Scholar
  • 34 Winn RK, Paulson JC, Harlan JM. A monoclonal antibody to P-selectin ameliorates injury associated with hemorrhagic shock in rabbits. Am. J. Physiol 1994; 267: H2391-H2397
    PubMedGoogle Scholar
  • 35 Ramamoorthy C, Sharar SR, Harlan JM, Tedder TF, Winn RK. Blocking L-selectin function attenuates reperfusion injury following hemorrhagic shock in rabbits. Am. J. Physiol 1996; 271: H1871-H1877
    PubMedGoogle Scholar