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Thromb Haemost 1997; 78(01): 266-270
DOI: 10.1055/s-0038-1657537
Platelet membrane glycoproteins
Schattauer GmbH Stuttgart

Platelet GPIb-V-IX Complex

Kenneth J Clemetson
Theodor Kocher Institute, University of Berne, Berne, Switzerland
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Publication History

Publication Date:
12 July 2018 (online)

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  • References

  • 1 Ruggeri ZM. The platelet glycoprotein Ib-IX complex. Prog Hemostas Thromb 1991; 10: 35-68
    PubMedGoogle Scholar
  • 2 Roth GJ. Developing relationships: Arterial platelet adhesion glycoprotein lb and leucine-rich glycoproteins. Blood 1991; 77: 5-19
    PubMedGoogle Scholar
  • 3 Løpez J. The platelet glycoprotein Ib-IX complex. Blood Coag Fibrinolysis 1994; 05: 97-119
    CrossrefPubMedGoogle Scholar
  • 4 Clemetson KJ, Clemetson JM. Platelet GPIb-V-IX complex: structure, function, physiology and pathology. Semin Thromb Hemostas 1995; 21: 130-136
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Kobe B, Deisenhofer J. The leucine-rich repeat: A versatile binding motif. TIBS 1994; 19: 415-421
    PubMedGoogle Scholar
  • 6 De MarcoL, Mazzucato M, Masotti A, Ruggeri ZM. Localization and characterization of an α-thrombin-binding site on platelet glycoprotein Ibα. J Biol Chem 1994; 269: 6478-6484
    PubMedGoogle Scholar
  • 7 Gralnick HR, Williams S, McKeown LP, Hansmann K, Fenton II JW, Krutzsch H. High-affinity α-thrombin binding to platelet glycoprotein Iba: Identification of two binding domains. Proc Natl Acad Sci USA 1994; 91: 6334-6338
    CrossrefPubMedGoogle Scholar
  • 8 Andrews RK, Fox JEB. Interaction of purified actin-binding protein with the platelet membrane glycoprotein Ib-IX complex. J Biol Chem 1991; 266: 7144-7147
    PubMedGoogle Scholar
  • 9 Cunningham JG, Meyer SC, Fox JE. The cytoplasmic domain of the α-subunit of glycoprotein (GP) lb mediates attachment of the entire GPIb-IX complex to the cytoskeleton and regulates von Willebrand factor induced changes in cell morphology. J Biol Chem 1996; 271: 11581-11587
    CrossrefPubMedGoogle Scholar
  • 10 Du X, Harris SJ, Tetaz TJ, Ginsberg MH, Berndt MC. Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex. J Biol Chem 1994; 269: 18287-18290
    PubMedGoogle Scholar
  • 11 Du X, Fox JE, Pei S. Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor platelet glycoprotein Ibα. J Biol Chem 1996; 271: 7362-7367
    CrossrefPubMedGoogle Scholar
  • 12 Meyer S, Zuerbig S, Cunningham CC, Hartwig JH, Bissell J, Gardner K, Fox JEB. Identification of the region in ABP that binds to the cytoplasmic domain of glycoprotein Ibα. J Biol Chem 1997; 272: 2914-2919
    CrossrefPubMedGoogle Scholar
  • 13 Dong J, Li CQ, Løpez JA. Tyrosine sulfation of the glycoprotein Ib-IX complex: Identification of sulfated residues and effect on ligand binding. Biochemistry 1994; 33: 13946-13953
    CrossrefPubMedGoogle Scholar
  • 14 Murata M, Furihata K, Ishida F, Russell SR, Ware J, Ruggeri ZM. Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ibα involved in platelet transfusion refractoriness. Blood 1992; 79: 3086-3090
    PubMedGoogle Scholar
  • 15 Løpez JA, Ludwig EH, McCarthy BJ. Polymorphism of human glycoprotein Ibα results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications. J Biol Chem 1992; 267: 10055-10061
    PubMedGoogle Scholar
  • 16 Ishida F, Firihata K, Ishida K, Yan J, Kitano K, Kiyosawa K, Furuta S. The largest variant of platelet glycoprotein Ibα has four tandem repeats of 13 amino acids in the macroglycopeptide region and a genetic linkage with methionine 145. Blood 1995; 86: 1356-1360
    PubMedGoogle Scholar
  • 17 Kobe B, Deisenhofer J. Crystal structure of porcine ribonucle-ase inhibitor, a protein with leucine-rich repeats. Nature 1993; 366: 751-756
    CrossrefPubMedGoogle Scholar
  • 18 Greco NJ, Tandon NN, Jones GD, Kornhauser R, Jackson B, Yamamoto N, Tanoue K, Jamieson GA. Contributions of glycoprotein lb and the seven transmembrane domain thrombin receptor to increases in platelet cytoplasmic [Ca2+] induced by a-thrombin. Biochemistry 1996; 35: 906-914
    CrossrefPubMedGoogle Scholar
  • 19 Kroll MH, Harris TS, Moake JL, Handin RI, Schafer AI. von Willebrand factor binding to platelet Gplβ initiates signals for platelet activation. J Clin Invest 1991; 88: 1568-1573
    CrossrefPubMedGoogle Scholar
  • 20 Chow TW, Heliums JD, Moake JL, Kroll MH. Shear stress-induced von Willebrand factor binding to platelet glycoprotein lb initiates calcium influx associated with aggregation. Blood 1992; 80: 113-120
    PubMedGoogle Scholar
  • 21 Kroll MH, Heliums JD, Guo Z, Durante W, Razdan K, Hrbolich JK, Schafer AI. Protein kinase C is activated in platelets subjected to pathological shear stress. J Biol Chem 1993; 268: 3520-3524
    PubMedGoogle Scholar
  • 22 Ikeda Y, Handa M, Kamata T, Kawano K, Kawai Y, Watanabe K, Kawakami K, Sakai K, Fukuyama M, Itagaki I, Yoshioka A, Ruggeri ZM. Transmembrane calcium influx associated with von Willebrand factor binding to GP lb in the initiation of sheare induced platelet aggregation. Thromb Haemost 1993; 69: 496-502
    Article in Thieme ConnectPubMedGoogle Scholar
  • 23 Oda A, Yokoyama K, Murata M, Tokuhira M, Nakamura K, Handa M, Watanabe K, Ikeda Y. Protein tyrosine phosphorylation in human platelets during shear stress-induced platelet aggregation (SIPA) is regulated by glycoprotein (GP) Ib/IX as well as GPIIb/IIIa and requires intact cytoskeleton and endogenous ADP. Thromb Haemost 1995; 74: 736-742
    Article in Thieme ConnectPubMedGoogle Scholar
  • 24 Razdan K, Heliums JD, Kroll MH. Shear stressinduced von Willebrand factor binding to platelets causes the activation of tyrosine kinase(s). Biochem.J 1993; 302: 661-666
    PubMedGoogle Scholar
  • 25 Gibbins J, Asselin J, Famdale R, Barnes M, Law C-L, Watson SP. Tyrosine phosphorylation of the Fc receptor ϒ;-chain in collagen-stimulated platelets. J Biol Chem 1996; 271: 18095-18099
    CrossrefPubMedGoogle Scholar
  • 26 Chacko GW, Duchemin A-M, Coggeshall KM, Osborne JM, Brandt JT, Anderson CL. Clustering of the platelet Fcϒ receptor induces non-covalent association with the tyrosine kinase p72syk . J Biol Chem 1994; 269: 32435-32440
    PubMedGoogle Scholar
  • 27 Clemetson KJ, Clemetson JM. Molecular abnormalities in Glanzmann’s thrombasthenia Bernard-Soulier syndrome and platelet-type von Willebrand’s disease. Current Opinion in Hematology 1994; 01: 388-393
    PubMedGoogle Scholar
  • 28 Miller JL, Cunningham D, Lyle VA, Finch CN. Mutation in the gene encoding the a chain of platelet glycoprotein lb in platelet-type von Willebrand disease. Proc Natl Acad Sci USA 1991; 88: 4761-4765
    CrossrefPubMedGoogle Scholar
  • 29 Bolin RB, Okumura T, Jamieson GA. New polymorphism of platelet membrane glycoproteins. Nature 1977; 269: 69-70
    CrossrefPubMedGoogle Scholar
  • 30 Hashimoto Y, Ware J. Identification of essential GATA and Ets binding motifs within the promotor of the platelet glycoprotein Ibα gene. J Biol Chem 1995; 270: 24532-24539
    CrossrefPubMedGoogle Scholar
  • 31 Ludlow LB, Schick BP, Budarf ML, Driscoll DA, Zackai EH, Cohen A, Konkle BA. Identification of a mutation in a GATA binding site of the platelet glycoprotein Ibβ promotor resulting in the Bernard-Soulier syndrome. J Biol Chem 1996; 271: 22076-22080
    CrossrefPubMedGoogle Scholar
  • 32 Hickey MJ, Roth GJ. Characterization of the gene encoding human platelet glycoprotein IX. J Biol Chem 1993; 268: 3438-3443
    PubMedGoogle Scholar
  • 33 Lanza F, Morales M, deLa SalleC, Cazenave J-P, Clemetson KJ, Shimomura T, Phillips DR. Cloning and characterization of the gene encoding the human platelet glycoprotein (GP) V. A member of the leucine-rich glycoprotein (LRG) family cleaved during thrombin-induced platelet activation. J Biol Chem 1993; 268: 20801-20807
    PubMedGoogle Scholar
  • 34 Usami Y, Fujimura Y, Suzuki M, Ozeki Y, Nishio K, Fukui H, Titani K. Primary structure of two-chain botrocetin, a von Willebrand factor modulator purified from the venom of Bothrops jararaca. Proc. Natl. Acad. Sci. USA 1993; 90: 928-932
    CrossrefPubMedGoogle Scholar
  • 35 Hamako J, Matsui T, Suzuki M, Ito M, Makita K, Fujimura Y, Ozeki Y, Titani K. Purification and characterization of bitiscetin, a novel von Willebrand factor modulator protein from Bitis arietans snake venom. Biochem Biophys Res Commun 1996; 226: 273-279
    CrossrefPubMedGoogle Scholar
  • 36 Peng M, Lu W, Beviglia L, Niewiarowski S, Kirby EP. Echicetin: A snake venom protein that inhibits binding of von Willebrand factor and alboaggregins to platelet glycoprotein lb. Blood 1993; 81: 2321-2328
    CrossrefPubMedGoogle Scholar
  • 37 Peng M, Lu W, Kirby EP. Alboaggregin-B: A new platelet agonist that binds to platelet membrane glycoprotein Ib. Biochemistry 1991; 30: 11529-11536
    CrossrefPubMedGoogle Scholar