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Thromb Haemost 1982; 48(03): 283-285
DOI: 10.1055/s-0038-1657281
Original Article
Schattauer GmbH Stuttgart

Decreased Levels of Histidine-Rich Glycoprotein (HRG) and Increased Levels of Free Plasminogen in Women on Oral Contraceptives Low in Estrogen

Jørgen Jespersen
1   The Section of Coagulation and Fibrinolysis, Division of Health Research TNO, Leiden, The Netherlands
,
Cornelis Kluft
2   Department of Clinical Chemistry, Ribe County Hospital in Esbjerg, Denmark and the Gaubius Institute, Division of Health Research TNO, Leiden, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 29 March 1982

Accepted 12 October 1982

Publication Date:
13 July 2018 (online)

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Summary

Determinations by immunologic methods of histidine-rich glycoprotein (HRG) and plasminogen, were made in plasma samples collected during one normal or hormone induced cycle in 15 young, normal women and in 11 women using oral contraceptives with 30 μg ethinyl estradiol and 150 μg levo-norgestrel. The hormone group showed an increase in plasminogen level to about 150% of normal, while the concentration of HRG was decreased to about 75% of normal. This resulted in a considerable relative increase in the concentration of free plasminogen in the hormone group (calculated from the equilibrium: HRG·plasminogen ⇌ HRG + plasminogen, using KD = 1.0 μM), representing a doubling of that in the normal group. Hence, more plasminogen is available for binding to fibrin and activation in the hormone group.

Keywords

Histidine-rich glycoprotein - Oral contraceptives - Plasminogen
 

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