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Thromb Haemost 1982; 48(02): 232-234
DOI: 10.1055/s-0038-1657263
Original Article
Schattauer GmbH Stuttgart

Effects of Ethanol Intoxication and Hangover on Plasma Levels of Thromboxane B2 and 6-Keto-Prostaglandin F1α and on Thromboxane B2 Formation by Platelets in Man

M Kangasaho
The Dept. of Biomedical Sciences, University of Tampere, Tampere, Finland and Dept. of Neurology, University of Helsinki, Helsinki, Finland
,
M Hillbom
The Dept. of Biomedical Sciences, University of Tampere, Tampere, Finland and Dept. of Neurology, University of Helsinki, Helsinki, Finland
,
M Kaste
The Dept. of Biomedical Sciences, University of Tampere, Tampere, Finland and Dept. of Neurology, University of Helsinki, Helsinki, Finland
,
H Vapaatalo
The Dept. of Biomedical Sciences, University of Tampere, Tampere, Finland and Dept. of Neurology, University of Helsinki, Helsinki, Finland
› Author Affiliations
Further Information

Publication History

Received 05 July 1982

Accepted after revision 24 August 1982

Publication Date:
13 July 2018 (online)

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Summary

We detected a significant decrease in plasma thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α (6-keto-PGF1α) levels together with a significant increase in plasma 6-keto-PGF1α/TXB2 ratio in young healthy non-alcoholic male volunteers after acute ingestion of ethanol (1.5 g/kg). Paradoxically, during ethanol intoxication and the following hangover a significant increase in ADP-induced formation of TXB2 by platelet rich plasma could be observed, which suggests that ethanol intoxication via some unknown mechanism sensitizes platelets to produce TXB2. Whether these observations contribute to the increased risks of subarachnoid haemorrhage or ischaemic brain infarction among occasional heavy drinkers recently described by us remains to be proved.

Keywords

Platelets - Ethanol - Thromboxanes - Prostaglandins - Prostacyclin
 

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