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Thromb Haemost 1982; 48(02): 217-221
DOI: 10.1055/s-0038-1657260
Original Article
Schattauer GmbH Stuttgart

Diagnosis of Heterozygotes in Glanzmann’s Thrombasthenia

H Stormorken
The Research Institute for Internal Medicine, Section of Hemostasis and Thrombosis, University of Oslo, Rikshospitalet, Oslo, Norway
,
G O Gogstad
The Research Institute for Internal Medicine, Section of Hemostasis and Thrombosis, University of Oslo, Rikshospitalet, Oslo, Norway
,
N O Solum
The Research Institute for Internal Medicine, Section of Hemostasis and Thrombosis, University of Oslo, Rikshospitalet, Oslo, Norway
,
H Pande
1   The Nordland Central Hospital, Bodø, Norway
› Author Affiliations
Further Information

Publication History

Received 06 July 1982

Accepted 23 August 1982

Publication Date:
13 July 2018 (online)

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Summary

A study of a family with a propositus suffering from classical thrombasthenia type I has shown that the new immunochemical methods detect heterozygotes with high reliability. There was no overlapping between heterozygotes and normals, and the concentration of the glycoprotein IIb-IIIa-complex is remarkably constant around 50–60% in the heterozygotes. Furthermore, heterozygotes as a group show an increased bleeding tendency.

Keywords

Thrombasthenia - Heterozygotes - Diagnosis - Laboratory - Clinical
 

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