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DOI: 10.1055/s-0038-1657171
Factor II Related Antigen and Antithrombin III Levels as Indicators of Liver Failure in Consumption Coagulopathy
Publication History
Received 16 November 1981
Accepted 18 March 1982
Publication Date:
13 July 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/198203/lookinside/thumbnails/10-1055-s-0038-1657171-1.jpg)
Summary
In order to detect impaired synthesis of blood coagulation factors associated to consumption coagulopathy, a simultaneous evaluation of factor II-related antigen (II rAg) and of antithrombin III (AT III) was carried out in 16 patients affected with severe defibrination. An in vitro preliminary study on plasma and serum demonstrated that the levels of II rAg and of AT III, assessed by the Laurell technique with Behring antisera, were not reduced by the coagulation process. The patients were, a posteriori, classified into two groups according to the absence (group A) or the presence (group B) of factors predisposing to liver failure such as metastasis, cirrhosis, and prolonged shock. II rAg and AT III levels are significantly correlated; they are in the normal range in group A but reduced in group B. Thus II rAg or AT III level determinations are useful markers in the detection of liver failure associated to the consumption phenomenon. These results also suggest that part of the decreased AT III levels reported in severe cases of disseminated intravascular coagulation may be the consequence of an associated liver failure.
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References
- 1 Corrigan JJ, Earnest DL. Factor II antigen in liver disease and warfarin-induced vitamin K deficiency: correlation with coagulant activity using echis venom. Am J Haematol 1980; 8: 249-255
- 2 Letrenne E, Cassigneul J, Sié P, Caranobe C, Vinel JP, Boneu B. Intérêt clinique du dosage de la prothrombine par méthode immunologique et par la staphylocoagulase. Méd et Hyg 1981; 39: 4282-4285
- 3 Hedner U, Nilsson IM. Antithrombin III in a clinical material. Thromb Res 1973; 3: 631-641
- 4 Duckert F. Behaviour of antithrombin III in liver disease. Scand J Gastroent 1973; 8 (Suppl. 19) 109-112
- 5 Mannucci L, Dioguardi N, Ninno E, Manucci PM. Value of normotest and antithrombin III in the assessment of liver function. Scand J Gastroent 1973; 8 (Suppl. 19) 103-107
- 6 Damus PS, Wallace GA. Immunologic measurement of antithrombin III-Heparin cofactor and α2 macroglobulin in disseminated intravascular coagulation and hepatic failure coagulopathy. Thromb Res 1975; 6: 27-38
- 7 Aurousseau MH, Angeli JL, Josso F. Antithrombin III versus prothrombin in liver cirrhosis. Haemostasis 1981; 10: 104-107
- 8 McKay EJ. Immunochemical analysis of active and inactive antithrombin III. Br J Haematol 1980; 46: 277-285
- 9 Bick RL, Dukes ML, Wilson WL, Fekete LF. Antithrombin III (AT III) as a diagnostic aid in disseminated intravascular coagulation. Thromb Res 1977; 10: 721-729
- 10 Braunstein KM, Dodds KA, Stewart G, Shull KC, Eurenius K. Heparin cofactor activity following thermal injury. Am J Clin Pathol 1978; 70: 632-636
- 11 Blauhut B, Necek S, Kramer H, Vinazzer H, Bergmann H. Activity of antithrombin III and effect of heparin on coagulation in shock. Thromb Res 1980; 19: 775-782
- 12 Bick RL, Bick MD, Fekete LF. Antithrombin III patterns in disseminated intravascular coagulation. Am J Clin Pathol 1980; 73: 577-583
- 13 Sharp AA. Diagnosis and management of disseminated intravascular coagulation. Br Med Bull 1977; 33: 265-272
- 14 Caen J, Larrieu M, Samama M. L’hémostase, méthodes d’exploration et diagnostic pratique. L’Expansion Scientifique éditeur. 1975
- 15 Laurell CB. Quantitative estimation of proteins by electrophoresis in agarose gels containing antibodies. Anal Biochem 1966; 15: 45-63
- 16 Binder B. On the complex formation of antithrombin III with thrombin. Gel-filtration studies on human plasma and serum. Thrombos Diathes Haemorrh 1973; 30: 280-283