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Thromb Haemost 1979; 42(05): 1425-1428
DOI: 10.1055/s-0038-1657042
DOI: 10.1055/s-0038-1657042
Original Article
Tranexamic Acid and Gastric Fibrinolysis in the Rat
Further Information
Publication History
Received 23 March 1979
Accepted 08 June 1979
Publication Date:
23 August 2018 (online)
Summary
An optimal inhibition of tissue fibrinolysis, studied by a histochemical fibrin slide technique in the rat stomach, was obtained by administration of tranexamic acid in a dose of 60 mg/100 g body weight. A significant fibrinolysis inhibition was found within 5 min, when tranexamic acid in this dose was given either intravenously or intragastrically. A prolonged duration of fibrinolysis inhibition was observed after intragastric administration. After 4 hr no inhibitory effect of tranexamic acid could be recorded, irrespective of the route of administration.
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