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Thromb Haemost 1964; 12(02): 489-504
DOI: 10.1055/s-0038-1655589
Originalarbeiten – Original Articles – Travaux Originaux
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Rôles of Surface Factor and a Plasma Inhibitory Activity (Anti-SF) During Experimental Thrombosis in Rabbits[*]

S. G Iatridis   **
1   Department of Physiology, University of North Carolina, Chapel Hill, N. C.
,
P. G Iatridis
1   Department of Physiology, University of North Carolina, Chapel Hill, N. C.
,
J. H Ferguson
1   Department of Physiology, University of North Carolina, Chapel Hill, N. C.
› Author Affiliations
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

Intravenous injection of active surface factor (SF) preparations, in rabbits, induces a thrombotic tendency, which correlates with a hypercoagulability of the blood revealed with the thrombelastograph. These effects are largely dissipated within 10 minutes post-injection. Portal vein injections, or confirmed occlusion of the liver circulation, fail to show that the SF inactivation has any direct connection with the liver. Rabbit plasma normally contains a high titer of inhibitor (anti-SF), which shows no significant increase after the SF injections. The inhibition is chiefly “progressive” in rabbit plasma. Plasma anti-SF could largely explain the nonpersistence of hypercoagulability and thrombo-genic activity in the 10 min post-injection tests. These mechanisms may be an important element in the body defenses against any thrombotic tendency associated with increased SF activity.

* Aided by USPHS Research Grant HE-01510-11 and NIH-(UNC) Institutional Research Grant HE-06350-03 for Thrombosis Research.


** Present Address: Department of Medicine, Athena Clinic, Victoros Hugo 12, Athinai, Greece.


 

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