Pharmakologische Grundlagen der Prostaglandin-Therapie

Marina Braun; K. Schrör

doi:10.1055/s-0038-1655212

Hämostaseologie, Table of Contents

Hamostaseologie 1993; 13(02): 53-57
DOI: 10.1055/s-0038-1655212

Ûbersichtsarbeiten/Review Articles

Schattauer GmbH

Pharmakologische Grundlagen der Prostaglandin-Therapie

Marina Braun

¹Institut für Pharmakologie der Heinrich-Heine-Universität Düsseldorf (Direktor: Prof. Dr. K. Schrör)

,

K. Schrör

¹Institut für Pharmakologie der Heinrich-Heine-Universität Düsseldorf (Direktor: Prof. Dr. K. Schrör)

› Author Affiliations

Abstract

Zusammenfassung

Vasodilatierende Prostaglandine werden zur Therapie fortgeschrittener Stadien der peripheren arteriellen Verschlußkrankheit und der Thrombangiitis obliterans eingesetzt. Der klinische Nutzen liegt vor allem in der therapeutischen Anwendung in Fällen, wo chirurgische Maßnahmen nicht angezeigt bzw. erfolglos geblieben sind. Eine Reihe von klinischen Studien belegt die klinische Wirksamkeit der systemischen Anwendung von Prostaglandin E₁ und lloprost. Die pharmakologischen Wirkungen dieser Substanzen betreffen nicht nur den Vasotonus, sondern auch Zellen des strömenden Blutes sowie das Fibrinolyseund Gerinnungssystem. Neuere experimentelle Befunde weisen auf eine antiatherosklerotische Wirkung der Prostaglandine hin.

Schlüsselwörter

Prostaglandine - Vasotonus - Thrombozyten - neutrophile Granulozyten - Fibrinolyse - Atherosklerose

Full Text

References

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