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Thromb Haemost 1963; 09(01): 074-089
DOI: 10.1055/s-0038-1654962
Originalarbeiten — Original Articles — Travaux Originaux
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Behaviour of Factors II, VII, IX, and X during Long-Term Treatment with Coumarin

E. A Loeliger
1   Department of Haematology of the Clinic for Internal Medicine (Director: Prof. Dr. ]. Mulder), University Hospital, and the Thrombosis Service (Head: Dr. E.A. Loeliger), Leyden, The Netherlands
,
B van der Esch
1   Department of Haematology of the Clinic for Internal Medicine (Director: Prof. Dr. ]. Mulder), University Hospital, and the Thrombosis Service (Head: Dr. E.A. Loeliger), Leyden, The Netherlands
,
M. J Mattern
1   Department of Haematology of the Clinic for Internal Medicine (Director: Prof. Dr. ]. Mulder), University Hospital, and the Thrombosis Service (Head: Dr. E.A. Loeliger), Leyden, The Netherlands
,
A. S. A den Brabander
1   Department of Haematology of the Clinic for Internal Medicine (Director: Prof. Dr. ]. Mulder), University Hospital, and the Thrombosis Service (Head: Dr. E.A. Loeliger), Leyden, The Netherlands
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Publication Date:
21 June 2018 (online)

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Summary

During long-term treatment with the long-acting coumarin derivative phenprocoumarol (marcoumar) no statistically significant difference in the depression of the activity of coagulation factors II, VII, IX, and X was found. The shorter-acting anticoagulants acenocoumarol (sintrom), warfarin sodium (coumadin), and dicoumarol, possibly lower factor IX somewhat less and factor X somewhat more than they do factors II and VII.

A 2.5-fold prolongation of the “prothrombin” time (using Owren 5 s human brain thromboplastin) and the same prolongation of the thrombotest time appear to correspond with a depression of all four factors from 100% down to approximately 20’%, the normal standard being a mixed population with a mean age of 29 years.

Separate determination of one of the four coagulation factors concerned is pointless; “prothrombin” time estimation, and more specifically thrombotest, still remain the most reliable methods for controlling the anti-vitamin K action of anticoagulants during long-term treatment.