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Thromb Haemost 1967; 17(03/04): 321-334
DOI: 10.1055/s-0038-1654156
Originalarbeiten - Original Articles - Travaux Originaux
Schattauer GmbH

Study of Thrombin-Coagulase

J. P Soulier
1   Centre National de Transfusion Sanguine, Paris
,
Odette Prou-Wartelle
1   Centre National de Transfusion Sanguine, Paris
,
with the technical assistance of,
Liliane Hallé
1   Centre National de Transfusion Sanguine, Paris
› Author Affiliations
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Publication History

Publication Date:
26 June 2018 (online)

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Summary

The preparation of thrombin-coagulase is described. The properties of thrombin-coagulase are compared with those of biothrombin: kinetics, thermostability, adsorption, chromatography, esterase activity, clotting activity, action on platelets and on factors V and VIII, susceptibility to inhibitors.

Biothrombin and thrombin-coagulase are closely related but distinct. Both apparently derive from prothrombin. Prothrombin and coagulase combine to form a complex: thrombin-coagulase wherein both factors are necessary for its activity. Possible explanations for the difference between thrombin-coagulase and biothrombin are proposed.

 

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