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Thromb Haemost 1971; 26(02): 341-352
DOI: 10.1055/s-0038-1653682
Originalarbeiten – Original Articles – Travaux Originaux
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Coagulation Studies in Acute Hepatic Necrosis

Effects on Coagulation of Extracorporeal Liver Perfusion and Exchange Blood Transfusion
H. J Böhmig M. D.
1   Department of Surgery, University of Colorado School of Medicine, and Veterans Administration Hospital, Denver, Colorado.
,
G. M Abouna M. D.
1   Department of Surgery, University of Colorado School of Medicine, and Veterans Administration Hospital, Denver, Colorado.
,
J. A Diez-Pardo M. D.
1   Department of Surgery, University of Colorado School of Medicine, and Veterans Administration Hospital, Denver, Colorado.
› Author AffiliationsSupported by United States Public Health Service grants AM-07721, AI-12148, AI-04152, AI-AM-08898, RR-00069 and HE-09110.
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Publication History

Publication Date:
28 June 2018 (online)

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Summary

In 2 patients with post-hepatitic acute hepatic necrosis, a complex coagulation defect characterized by low levels of prothrombin, factor V, and factor IX, hypofibrinogenemia, thrombocytopenia, and pathologic thrombin time was present. Levels of factor VIII were abnormally elevated. Exchange blood transfusions led to striking but shortlasting improvement in coagulation and were found to be an efficient means in control of bleeding. Extracorporal perfusion of the livers of pigs, and of a human liver raised the levels of the liver-synthesized clotting factors prothrombin, factor V, and factor IX in the patient’s blood. Increase of fibrinogen level occurred solely after 36 h perfusion of a human liver. Adverse effects of extracorporeal liver perfusion were decrease of platelets, fibrinogen, and factor VIII.


 

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