Download PDF
Thromb Haemost 1969; 21(02): 373-379
DOI: 10.1055/s-0038-1653548
Originalarbeiten - Original Articles - Travaux Originaux
Schattauer GmbH

The Effect of Adenosine Phosphates on the Spreading of Normal Human Platelets

H Linker
1   Medical Clinic of the University of Cologne (Head: Prof. Dr. E. Gross)
,
H Reuter
1   Medical Clinic of the University of Cologne (Head: Prof. Dr. E. Gross)
› Author Affiliations
Further Information

Publication History

Publication Date:
10 June 2018 (online)

Also available at
    Permissions and Reprints

Summary

The spreading of human platelets requires the presence of ADP as do other platelet functions. In the plasma of patients with a failure of release of ADP from the platelets the also decreased ability to spread can be normalized by exogenous ADP. AMP and ATP inhibit the spreading of platelets.

 

  • References

  • 1 Bloom A. L, Davies A. J. Adenosine Diphosphate and the Measurement of Platelet Adhesiveness. J. clin. Path 20: 706 1967;
    CrossrefPubMedSearch in Google Scholar
  • 2 Born G. V. R. The breakdown of adenosine triphosphate in blood platelets during clotting. J. Physiol. (Lond.) 133: 61P-62P 1956;
    PubMedSearch in Google Scholar
  • 3 Born G. V. R. Adenosinetriphosphate in Blood Platelets. Biochem. J 62: 33 1956;
    PubMedSearch in Google Scholar
  • 4 Born G. V. R. Uptake of adenosine and of adenosine diphosphate by human blood platelets. Nature (Lond.) 206: 1121-1122 1965;
    CrossrefPubMedSearch in Google Scholar
  • 5 Born G. V. R. Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal. Nature (Lond.) 194: 927-929 1962;
    PubMedSearch in Google Scholar
  • 6 Born G. V. R. Strong inhibition by 2-chloradenosine of the aggregation of blood platelets by adenosine diphosphate. Nature (Lond.) 202: 95 1964;
    PubMedSearch in Google Scholar
  • 7 Born G. V. R, Gross M. J. Inhibition of the aggregation of blood platelets by substances related to adenosine diphosphate. J. Physiol. (Lond.) 166: 29P-30P 1983;
    PubMedSearch in Google Scholar
  • 8 Born G. V. R, Cross M. J. The aggregation of blood platelets. J. Physiol. (Lond.) 168: 178-195 1963;
    CrossrefPubMedSearch in Google Scholar
  • 9 Born G. V. R, Cross M. J. Effect of adenosine diphosphate on the concentration of platelets in circulating blood. Nature (Lond.) 197: 974 1963;
    CrossrefPubMedSearch in Google Scholar
  • 10 Born G. V. R, Haslam R. J, Goldman M, Lowe R. D. Comparative effectiveness of adenosine analogues as inhibitors of blood-platelets aggregation and as vasodilators in man. Nature (Lond.) 205: 678 1965;
    CrossrefPubMedSearch in Google Scholar
  • 11 Braunsteiner H. Thrombopathie und Thrombasthenie. Beih. zu Wien. Z. inn. Med 36 1955;
    PubMedSearch in Google Scholar
  • 12 Braunsteiner H, Fellinger K, Pakesch F. Elektronenmikroskopische Beobachtungen der Blutplättchen bei Thrombasthenie. Klin. Wschr 31: 21 1953;
    CrossrefPubMedSearch in Google Scholar
  • 13 Breddin K. Zur Messung der Thrombozytenadhäsivität. Thrombos. Diathes. haemorrh. (Stuttg.) 12: 269 1964;
    PubMedSearch in Google Scholar
  • 13a Breddin K, Bruch K. H. Zur Klinik der Thrombozytenfunktionsstörungen unter besonderer Berücksichtigung der Ausbreitungsfähigkeit der Thrombozyten an silikonisierten Glasflächen. Thrombos. Diathes. haemorrh. (Stuttg.) 09: 525-545 1963;
    PubMedSearch in Google Scholar
  • 13b Breddin K, Langbein H. Über den Einfluß verschiedener Stoffwechselhemmer auf die Thrombozytenfunktion. Thrombos. Diathes. haemorrh. (Stuttg.) 10: 29-41 1963;
    PubMedSearch in Google Scholar
  • 14 Clayton S, Born G. V. R, Cross M. J. Inhibition of the aggregation of blood platelets by nucleosides. Nature (Lond.) 200: 138-139 1963;
    CrossrefPubMedSearch in Google Scholar
  • 15 Constantine J. W. Temperature and the Aggregation of Rabbit Platelets by Adenosine Diphosphate. Nature (Lond.) 205: 1075-1077 1965;
    CrossrefPubMedSearch in Google Scholar
  • 16 Constantine J. W. Aggregation and Adhesion of Rat Platelets. Nature (Lond.).. 214. 1084 bis 1086 1967
    PubMedSearch in Google Scholar
  • 17 Gaarder A, Laland S. Hypothesis for the Aggregation of Platelets by Nucleotides. Nature (Lond.) 202: 909-910 1964;
    CrossrefPubMedSearch in Google Scholar
  • 18 Gaarder A, Jonsen J, Laland S, Hellem A, Owren P. A. Adenosine Diphosphate in Red Cells as a Factor in the Adhesiveness of Human Blood Platelets. Nature (Lond.) 192: 531-532 1961;
    CrossrefPubMedSearch in Google Scholar
  • 19 Gross R. Aktuelle Probleme des Thrombozytenersatzes. Ber. 7. Tag. Dtsch. Ges. Bluttransf., Berlin 1958, Bibi, haemat. (Basel.) 09: 92 1959;
    PubMedSearch in Google Scholar
  • 20 Gross R. Pathophysiologie und Klinik der Thrombozytopa4/26/2017 10:20AMthien. Yerh. dtsch. Ges. inn. Med. 66. Kongr 814 1960;
    PubMedSearch in Google Scholar
  • 21 Gross R, Gerok W, Löhr G. W, Vogel W, Waller H. D, Theopold W. Über die Natur der Thrombasthenie Thrombopathie Glanzmann-Naegeli. Klin. Wschr 38: 193 1960;
    CrossrefPubMedSearch in Google Scholar
  • 22 Gross R, Löhr G. W, Waller H. D. Long term preservation of functionally intact platelets. Proc. 7th Congr. europ. soc. haemat. London 1959 Part II 686 1960
    PubMedSearch in Google Scholar
  • 23 Gross R, Niemeyer G, Reuter H. Ein methodischer Beitrag zur Funktionsprüfung menschlicher Blutplättchen unter standardisierten Bedingungen. Dtsch. med. Wschr. (Im Druck.)
    PubMed
  • 24 Gross R, Kahlstorf J, Nies D. Platelet aggregation from functional and biochemical points of view. X th Congress of the international society of Haematology.
    PubMed
  • 25 Hampton J. R, Mitchell J. R. A. An estimate of the Number of Adenosine Diphosphate Binding sites on Human Platelets. Nature (Lond.) 211: 245-246 1966;
    CrossrefPubMedSearch in Google Scholar
  • 26 Hovig T, Holmsen H. Release of a platelet-aggregating substance (adenosine diphosphate. from rabbit blood platelets induced by saline “extract” of tendons. Thrombos. Diathes. haemorrh. (Stuttg.) 09: 264-278 1963;
    PubMedSearch in Google Scholar
  • 27 Hürter H. Ein methodischer Beitrag zur Ausbreitungsfähigkeit menschlicher Blutplättchen an silikonisierten Oberflächen. Inaug. Diss. Köln. (In Vorbereitung.)
    PubMed
  • 28 Kröhl R, Wenzel E, Breddin K. Stoffwechselhemmung und Thrombozytenfunktion. Verh. dtsch. Ges. inn. Med 73: 399 1967;
    PubMedSearch in Google Scholar
  • 29 Löhr G. W. Differentialdiagnose und Pathogenese der hereditären Thrombopathien. Med. Welt 771 1961;
    PubMedSearch in Google Scholar
  • 30 Löhr G. W, Waller H. D. Zellstoffwechsel und Zellalterung. Klin. Wschr 37: 833 1959;
    CrossrefPubMedSearch in Google Scholar
  • 31 Macmillan D. G. Secondary clumping effect in human citrated platelet-rich plasma produced by adenosine diphosphate and adrenaline. Nature (Lond.) 211: 140-144 1966;
    CrossrefPubMedSearch in Google Scholar
  • 32 Macmillan D. G, Oliver M. F. The initial changes in platelet morphology following the addition of adenosine diphosphate. J. atheroscler. Res 05: 440-444 1965;
    CrossrefPubMedSearch in Google Scholar
  • 33 Marcus A. J, Zucker M. B. The Physiology of Blood Platelets. Grune and Stratton, Inc; New York, London: 1965
    Search in Google Scholar
  • 34 Mitchell J. R. A, Sharjp A. A. Platelet Clumping in vitro. Brit. J. Haemat 10: 78-93 1964;
    CrossrefPubMedSearch in Google Scholar
  • 35 Mustard J. F, Hegardt B, Rosseil H. G, MacMillan R. L. Effect of adenosine nucleotides on platelet aggregation and clotting time J. Lab. clin. Med 64: 548 1964;
    PubMedSearch in Google Scholar
  • 36 Niemeyer G, Reuter H. Zur Zählung und Funktionsprüfung der Blutplättchen. Internist 09: 48-55 1968;
    PubMedSearch in Google Scholar
  • 37 Niemeyer G, Reuter H, Gross R. Unveröffentlicht.
    PubMed
  • 38 O’Brien J. R. Some effects of the adenosine phosphates, thrombin and cocaine upon platelet adhesiveness. J. clin. Path 15: 446-455 1962;
    CrossrefPubMedSearch in Google Scholar
  • 39 O’Brien J. R. A comparison of platelet aggregation produced by seven compounds and a comparison of their inhibitors. J. clin. Path 17: 275-281 1964;
    CrossrefPubMedSearch in Google Scholar
  • 40 O’Brien J. R. Platelet stickiness. Ann. Rev. Med 17: 275 1966;
    CrossrefPubMedSearch in Google Scholar
  • 40a O’Brien J. R. Platelets: A Portsmouth Syndrome. Lancet 1967; 285.
    PubMedSearch in Google Scholar
  • 41 Reuter H, Linker H. The Effect of Urea on Aggregation and Incubation Resistance of human Platelets. (In Vorbereitung.)
    PubMed
  • 42 Reuter H, Niemeyer G, Gross R. Zur Differenzierung der Plättchenaggregation. Intern. Sympos. über Stoffwechsel u. Membranpermeabilität von Erythrozyten und Thrombozyten. Wien 1968. Thieme, Stuttgart (Im Druck).
    PubMed
  • 43 Sinakos Z, Gaen J. Agrégabilité des plaquettes de diverses espèces animales (Etude microscopique et photometrique). Nouv. Rev. franç. Hémat 07: 120 1967;
    PubMedSearch in Google Scholar
  • 44 Waller H. D, Gross R. Genetische Enzymdefekte als Ursache von Thrombopathien. Verh. dtsch. Ges. inn. Med. 70 Kongr. S 475 1964;
    PubMedSearch in Google Scholar
  • 45 Waller H. D, Löhr G. W, Grignani F, Gross R. Über den Energiestoffwechsel normaler menschl. Thrombozyten. Thrombos. Diathes. haemorrh. (Stuttg.) 03: 520 1959;
    PubMedSearch in Google Scholar
  • 46 Zucker M. B, Zaccardi J. B. Coagulation I. Platelet shape change induced by adenosine diphosphate and prevented by adenosine monophosphate. Fed. Proc 23: 299 1964;
    PubMedSearch in Google Scholar