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Thromb Haemost 1969; 21(02): 223-233
DOI: 10.1055/s-0038-1653531
Originalarbeiten - Original Articles - Travaux Originaux
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Studies on Tissue Thromboplastin - Electron Micrography

M Hvatum
1   Department of Microbiology, Dental Faculty, and Department of Pathology, University Clinic, University of Oslo, Oslo 3, Norway
,
T Hovig
1   Department of Microbiology, Dental Faculty, and Department of Pathology, University Clinic, University of Oslo, Oslo 3, Norway
,
H Prydz
1   Department of Microbiology, Dental Faculty, and Department of Pathology, University Clinic, University of Oslo, Oslo 3, Norway
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Publication Date:
10 June 2018 (online)

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Summary

The ultrastructure of tissue thromboplastin from human brain, purified by sodium deoxycholate extraction and gel filtration, has been studied. A correlation is found between the reaggregation of solubilized thromboplastin, the reappearance of procoagulant activity, and the formation of concentric membraneous structures.

Sodium deoxycholate splits tissue thromboplastin into two fractions, A and B. The ultrastructure of fraction B, which contains 80-90% phospholipid, has been studied.

 

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