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Thromb Haemost 1981; 46(04): 687-689
DOI: 10.1055/s-0038-1653453
Original Article
Schattauer GmbH Stuttgart

HLA Antigens and Factor VIII Antibody in Classic Hemophilia

European Study Group of Factor VIII Antibody
D Frommel
The Participating Centers: I.N.S.E.R.M. U 56 & Clinique de Pédiatrie Université Paris-Sud, Bicêtre
,
J P Allain
Internats médico-pédagogiques pour Jeunes hémophiles de la Croix Rouge franҫaise, Centre Air & Soleil
,
E Saint-Paul
Centre E. Rémigy
,
C Bosser
Centre I’Espoir, France
,
B Noël
Centre I’Espoir, France
,
P M Mannucci
Ospedale Policlinico, Milano
,
F Pannicucci
Spedali Riuniti di San Chiara, Pisa, Italy
,
M Blombäck
Karolinska Sjukhuset, Stockholm, Sweden
,
O Prou-Wartelle
Tissue Typing Laboratories, Centre National de Transfusion Sanguine, Paris
,
J Y Muller
Tissue Typing Laboratories, Centre National de Transfusion Sanguine, Paris
› Author Affiliations
Further Information

Publication History

Received 04 April 1981

Accepted 14 September 1981

Publication Date:
05 July 2018 (online)

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Summary

Possible interrelations between the immune response factor VIII and the major histocompatibility system were investigated in 57 multi-transfused hemophilic brothers belonging to 26 families. Linkage appears very unlikely although formal proof of independence cannot be offered. The HLA system, therefore, does not provide markers predictive for the development of antibodies to factor VIII in severe hemophilia A.

Keywords

Hemophilia - HLA antigens - Factor VIII antibody - Immunogenetics - Specific immune responsiveness
 

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