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Thromb Haemost 1981; 46(03): 645-647
DOI: 10.1055/s-0038-1653438
DOI: 10.1055/s-0038-1653438
Original Article
Stability of Prostacyclin in Human Plasma and Whole Blood: Studies on the Protective Effect of Albumin
Further Information
Publication History
Received 10 June 1981
Accepted 18 August 1981
Publication Date:
05 July 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/198103/lookinside/thumbnails/10-1055-s-0038-1653438-1.jpg)
Summary
The biological half-life of prostacyclin in Krebs solution, human cell-free plasma or whole blood was measured by bracket assay on ADP-induced platelet aggregation. At 37°C, pH 7.4, plasma and blood reduced the rate of loss of antiaggregatory activity compared with Krebs solution. The protective effect of plasma was greater than that of whole blood. This effect could be partially mimicked by the addition of human or bovine serum albumin to the Krebs solution. The stabilisation afforded by human serum albumin was dependent on the fatty acid content of the albumin, although this was less important for bovine serum albumin.
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