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Thromb Haemost 1981; 46(03): 575-580
DOI: 10.1055/s-0038-1653421
Original Article
Schattauer GmbH Stuttgart

Coagulation and Fibrinolysis Study in Systemic Lupus erythematosus: Haematological, Urinary and Tissue Parameters[*]

P Stratta
*   Cattedra di Nefrologia Medica dell’Università di Torino, Ospedale Maggiore di S. Giovanni Battista e dellaa Città di Torino, Italy
,
C Canavese
*   Cattedra di Nefrologia Medica dell’Università di Torino, Ospedale Maggiore di S. Giovanni Battista e dellaa Città di Torino, Italy
,
P Valmaggia
*   Cattedra di Nefrologia Medica dell’Università di Torino, Ospedale Maggiore di S. Giovanni Battista e dellaa Città di Torino, Italy
,
M Rotunno
*   Cattedra di Nefrologia Medica dell’Università di Torino, Ospedale Maggiore di S. Giovanni Battista e dellaa Città di Torino, Italy
,
E Levi
**   Banca del Sangue e del Plasma della Città di Torino, Fondazione G. Strumia, Ospedale Maggiore di S. Giovanni Battista e dellaa Città di Torino, Italy
,
A Bulla
**   Banca del Sangue e del Plasma della Città di Torino, Fondazione G. Strumia, Ospedale Maggiore di S. Giovanni Battista e dellaa Città di Torino, Italy
,
A Vercellone
*   Cattedra di Nefrologia Medica dell’Università di Torino, Ospedale Maggiore di S. Giovanni Battista e dellaa Città di Torino, Italy
› Author Affiliations
Further Information

Publication History

Received 25 January 1980

Accepted 29 July 1981

Publication Date:
05 July 2018 (online)

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Summary

Haematochemical, urinary and tissue parameters were examined in the elaboration of the coagulation and fibrinolysis profile in 33 cases of systemic lupus erythematosus in different stages of the disease. Coagulation abnormalities varied from hypo- to hyper-coagulabitity, these being often associated in the same patient, either simultaneously or at different stages of the disease. Activation of coagulation, closely related to the immunological activity of the disease, was present in 80% cases in the acute stage, and 36% of those in the remission stage. The lupus-like anticoagulant was not much involved, and platelets were the prime figures in the haemostatic abnormalities of lupus, those being the preferred target of direct antibody activities, or possibly of immune complexes as well. Activation of the coagulatory cascade is not uncommonly accompanied by a thrombophilic tendency coupled with signs of consumption, this being the expression of a continuously stimulated haemostatic balance.

Keywords

Systemic lupus erythematosus - Coagulation and fibrinolysis abnormality - Platelet disorders - Disseminated intravascular coagulation

* A preliminary report of work described here was presented at the Interdisciplinary Congress on Laboratory Diagnosis of Kidney and Urinary Tract Disease, Florence, Italy, November 21-24, 1979


 

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