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Thromb Haemost 1981; 46(02): 496-499
DOI: 10.1055/s-0038-1653395
Original Article
Schattauer GmbH Stuttgart

The Influence of Sex Hormones on Rat Platelet Sensitivity to Adenosine-Diphosphate

M A Orchard
The Department of Pharmacology, Chelsea College, University of London, London, U.K.
,
J H Botting
The Department of Pharmacology, Chelsea College, University of London, London, U.K.
› Author Affiliations
Further Information

Publication History

Received 05 February 1981

Accepted 29 April 1981

Publication Date:
26 July 2018 (online)

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Summary

The sensitivity of rat platelets to the aggregating agent adenosine-diphosphate (ADP) was studied. Platelets from male and female rats demonstrated comparable sensitivity. Neither ovariectomy nor castration altered platelet sensitivity to ADP. However platelets from mock-operated female, but not mockoperated male rats were less sensitive. Administration of physiological doses of l7β-oestradiol to ovariectomised rats reduced platelet sensitivity. Administration of l7β-oestradiol to mock operated female rats increased platelet sensitivity to ADP. The results suggest that physiological amounts of oestrogen induce a loss of platelet sensitivity following surgery or stress, whereas higher concentrations of oestrogens increase platelet sensitivity.

Keywords

Platelet aggregation - Adenosine-diphosphate - Sex hormones
 

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