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Thromb Haemost 1981; 46(01): 135
DOI: 10.1055/s-0038-1652366
Platelets – XI: Methods, Constituents, Function
Schattauer GmbH Stuttgart

Effects Of Hemostatic Agents On Platelet Aggregation

P N Sawyer
The Biophysics and Electrochemistry Laboratories and the Vascular Surgical Services, the Departments of Surgery and Surgical Research, State University of New York, the Downstate Medical Center, Brooklyn, New York
,
G Schwann
The Biophysics and Electrochemistry Laboratories and the Vascular Surgical Services, the Departments of Surgery and Surgical Research, State University of New York, the Downstate Medical Center, Brooklyn, New York
,
B Stanczewski
The Biophysics and Electrochemistry Laboratories and the Vascular Surgical Services, the Departments of Surgery and Surgical Research, State University of New York, the Downstate Medical Center, Brooklyn, New York
,
M T Jones
The Biophysics and Electrochemistry Laboratories and the Vascular Surgical Services, the Departments of Surgery and Surgical Research, State University of New York, the Downstate Medical Center, Brooklyn, New York
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Publication Date:
24 July 2018 (online)

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Several new collagen derived hemostatic agents have been introduced into the surgical armamentarium. The presumption is they produce platelet aggregation, ADP release and blood clotting through the intrinsic system.

Studies of interreaction of these new hemostatic agents with both blood and platelets suggests that the type of reaction with whole blood is not known or due to primary platelet activation. Avitene interreacts in part by platelet aggregation but also by interreacting with other components in blood including fibrinogen.

The available evidence with a new dissolving collagenous hemostat, “Superstat”™ indicates probable activation of the extrinsic coagulation system, directly converting prothrombin to thrombin, and fibrinogen to fibrin. Thrombin time ratios (experimental vs. control) are Superstat 1% - 0.81 ± 0.16/0.93 ± 0.06, Superstat 2% - 0.84 ± 0.11/0.93 ± 0.06, Superstat 3% - 0.61 ± 0.15/0.71 ± 0.02. Comparative studies have been completed on several other agents, among them, Kollagen Haemo. Vlies - 0.66 ± 0.1/0.71 ± 0.02, Gelfoam - 0.75 ± 0.15/0.71 ± 0.02, Surgicel - 0.73 ± 0.4/ 0.71 ± 0.02, Avitene - 0.75 ± 0.3/0.71 ± 0.02, Collatamp - 0.73 ± 0.4/0.71 ± 0.02. Derived data from thrombin times, clotting times and, when possible, platelet aggregation displays widely different rates of thrombus formation. We believe the enzymatic mechanisms for these reactions are currently only partially known.

The fact that clinically useful hemostatic agents each appear to produce hemostasis by several routes, and do not all use the same route, is of extreme interest in basic thrombosis studies as well as in clinical surgery.