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Thromb Haemost 1993; 69(01): 088
DOI: 10.1055/s-0038-1651556
Letter to the Editor
Schattauer GmbH Stuttgart

Inactivation of High and Low Molecular Weight Single-Chain Urokinase-Type Plasminogen Activator (Pro-Urokinase) by Thrombin in the Presence of Thrombomodulin

G A W de Munk
1   IVVO-TNO Gaubius Laboratory, Leiden, The Netherlands
,
A Molinari
2   Farmitalia Carlo Erba, Erbamont Group, Milano, Italy
,
D C Rijken
1   IVVO-TNO Gaubius Laboratory, Leiden, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 09 July 1992

Accepted after revision 05 August 1992

Publication Date:
04 July 2018 (online)

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  • References

  • 1 De Munk GAW, Groeneveld E, Rijken DC. Acceleration of the thrombin inactivation of single chain urokinase-type plasminogen activator (pro-urokinase) by thrombomodulin. J Clin Invest 1991; 88: 1680-1684
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  • 2 Molinari A, Giorgetti C, Lansen J, Vaghi F, Orsini G, Faioni EM, Mannucci PM. Thrombomodulin is a cofactor for thrombin degradation of recombinant single-chain urokinase plasminogen activator “in vitro” and in a perfused rabbit heart model. Thromb Haemostas 1992; 67: 226-232
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  • 3 Lijnen HR, Nelles L, Holmes WE, Collen D. Biochemical and thrombolytic properties of a low molecular weight form (comprising Leu144 through Leu411) of recombinant single-chain urokinase-type plasminogen activator. J Biol Chem 1988; 263: 5594-5598
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