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Thromb Haemost 1968; 19(01/02): 094-098
DOI: 10.1055/s-0038-1651185
Originalarbeiten – Original Articles – Travaux Originaux
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Studies on Thrombolysis with Streptokinase

I. On the Penetration of Streptokinase into Thrombi
R Gottlob
1   Department of Experimental Surgery (Head: Prof. Gottlob) of the First Surgical Clinic (Head: Prof. Fuchsig) Vienna University
,
G Blümel
1   Department of Experimental Surgery (Head: Prof. Gottlob) of the First Surgical Clinic (Head: Prof. Fuchsig) Vienna University
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

In vitro whole blood clots were incubated in SK, washed several times in Ringer-solution and then introduced into plasminogen solution. These clots showed marked signs of lysis surpassing those observed in clots that had only been incubated in SK. There was a correlation between the duration of the SK incubation and the clot lysis in the plasminogen solution. We deduce from these findings that SK enters the clots by diffusion and that this process lasts several hours.

If SK-incubated clots are placed into an SK-free environment, the SK slowly diffuses out of the thrombi.

Even in contact with very slight plasminogen concentrations, SK-incubated clots undergo distinct degrees of lysis.

 

  • References

  • 1 Dudok de Wit C. The Role of Plasminogen in Fibrinolysis. Vox Sang. 1962; 7: 526
    CrossrefPubMedGoogle Scholar
  • 2 Gottlob R, Blümel G. Warum lassen sich Vollblutgerinnsel mit Streptokinase nur unvollständig auflösen?. Klin. Med. 1964; 19: 405
    PubMedGoogle Scholar
  • 3 Gottlob R, Blümel G. Über den Nachweis der Plasminogenverarmung in retrahierten Vollblutgerinnseln und über deren Bedeutung für die Lysierbarkeit mit Streptokinase. Thrombos. Diathes. haemorrh. (Stuttg.) 1966; 15: 570
    PubMedGoogle Scholar
  • 4 Gross R. Blutgerinnung und Fibrinolyse. II. Streptase-Kolloquium Bad Nauheim. Jan. 30—31, 1964. Behringwerk-Mitteilungen 1964; 44: 1
    PubMedGoogle Scholar
  • 5 Hedner U, Nilsson I.M, Robertson B. Determination of Plasminogen in Clots and Thrombi. Thrombos. Diathes. haemorrh. (Stuttg.) 1966; 16: 38
    PubMedGoogle Scholar
  • 6 Ogston D, Ogston C.M, Fidlerton H.W. The Plasminogen Content of Thrombi. Thrombos. Diathes. haemorrh. (Stuttg.) 1966; 15: 220
    PubMedGoogle Scholar
  • 7 Piza F, Gottlob R, Blümel G. Zur Frage der Retraktion intravital entstandener Blutgerinnsel. Klin. Med. 1967; 22: 97
    PubMedGoogle Scholar
  • 8 Schmidt H.W. Zur thrombolytischen Therapie mit Streptokinase. Dtsch. med. Wschr. 1963; 28: 1407
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Schmidt H.W. In: vitro Untersuchungen zur Frage der Fibrinolyse und Thrombolyse durch Streptokinase. Klin. Wschr. 1963; 20: 1010
    PubMedGoogle Scholar
  • 10 Verstraete M, Vermylen J, Amery A, Vermylen G. Thrombolytic Therapy with Streptokinase Using a Standard Dosage Scheme. Brit. med. J. 1966; I: 454
    PubMedGoogle Scholar