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Thromb Haemost 1968; 19(01/02): 064-069
DOI: 10.1055/s-0038-1651181
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

The Effect of Urea on the Aggregation of Normal Human Platelets

J. B Somer   *
1   Department of Haematology, Royal Prince Alfred Hospital, Sydney
2   Department of Medicine, University of Sydney and the Renal Unit and Medical Research Department, Kanematsu Memorial Institute, Sydney Hospital, Sydney Australia
,
J. H Stewart
1   Department of Haematology, Royal Prince Alfred Hospital, Sydney
2   Department of Medicine, University of Sydney and the Renal Unit and Medical Research Department, Kanematsu Memorial Institute, Sydney Hospital, Sydney Australia
,
P. A Castaldi
1   Department of Haematology, Royal Prince Alfred Hospital, Sydney
2   Department of Medicine, University of Sydney and the Renal Unit and Medical Research Department, Kanematsu Memorial Institute, Sydney Hospital, Sydney Australia
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Publikationsdatum:
27. Juni 2018 (online)

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Summary

Studies have been performed on the effect of urea on platelet aggregation. Over a wide concentration range, urea initially inhibits and later enhances aggregation induced by ADP, thrombin, adrenaline and nor-adrenaline. Urea induces aggregation by a mechanism which differs from that due to ADP and it is suggested that this may reflect platelet damage. Urea alone cannot be held responsible for the qualitative platelet abnormalities and bleeding tendency of the uraemic state, but it may number among a group of harmful influences.

* Supported by the Post-Graduate Medical Foundation of the University of Sydney.


 

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