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Thromb Haemost 1987; 57(02): 137-139
DOI: 10.1055/s-0038-1651081
Original Article
Schattauer GmbH Stuttgart

A Selective Depression of Tissue Plasminogen Activator (t-PA) Activity in Euglobulins Characterises a Risk Group Among Survivors of Acute Myocardial Infarction[*]

Jørgen Gram
The Section of Coagulation and Fibrinolysis, Department of Clinical Chemistry and Department of Internal Medicine, Ribe County Hospital in Esbjerg, Esbjerg; and Section of Thrombosis Research, South Jutland University Centre, Esbjerg, Denmark
,
Jørgen Jespersen
The Section of Coagulation and Fibrinolysis, Department of Clinical Chemistry and Department of Internal Medicine, Ribe County Hospital in Esbjerg, Esbjerg; and Section of Thrombosis Research, South Jutland University Centre, Esbjerg, Denmark
› Author Affiliations
Further Information

Publication History

Received 14 October 1986

Accepted after revision 10 December 1986

Publication Date:
23 July 2018 (online)

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Summary

Among 29 patients recovering from a first-time acute myocardial infarction (AMI) 9 patients suffered reinfarction during a four year follow-up period. The 9 reinfarction patients were found to belong to a subgroup of 17 patients with a selective depression to near zero of euglobulin t-PA activity. None of the group of 12 patients with marked t-PA activity suffered a relapse. Euglobulin fibrinolytic activity as usually assayed did not distinguish between groups with or without relapse.

Keywords

Fibrinolysis - Acute myocardial infarction - Tissue type plasminogen activator - Intrinsic plasminogen activators - C1-inactivator - Euglobulins

* Undertaken within the framework of the Concerted Action “Thrombosis and Disabilities” (ECAT) of the Commission of the European Communities.


 

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