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Thromb Haemost 1987; 57(01): 059-061
DOI: 10.1055/s-0038-1651062
Original Articles
Schattauer GmbH Stuttgart

Measurement of Crosslinked Fibrin Derivatives -Use in the Diagnosis of Venous Thrombosis

Beverley J Rowbotham
1   The Department of Pathology, Royal Brisbane Hospital, Brisbane, Australia
,
Patrick Carroll
2   The Division of Medicine, Princess Alexandra Hospital, Brisbane, Australia
,
Alan N Whitaker
3   The Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
,
Ian H Bunce
1   The Department of Pathology, Royal Brisbane Hospital, Brisbane, Australia
,
Ralph G Cobcroft
2   The Division of Medicine, Princess Alexandra Hospital, Brisbane, Australia
,
Mervyn J Elms
1   The Department of Pathology, Royal Brisbane Hospital, Brisbane, Australia
,
Paul P Masci
3   The Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
,
Peter G Bundesen
4   The Centre for Applied Immunology, School of Health Science, Queensland Institute of Technology, Brisbane, Australia
,
Denis B Rylatt
4   The Centre for Applied Immunology, School of Health Science, Queensland Institute of Technology, Brisbane, Australia
,
Anthony J Webber
4   The Centre for Applied Immunology, School of Health Science, Queensland Institute of Technology, Brisbane, Australia
› Author Affiliations
Further Information

Publication History

Received 16 May 1986

Accepted after revision 11 November 1986

Publication Date:
06 July 2018 (online)

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Summary

The measurement of crosslinked fibrin derivatives in plasma has received evaluation as a screening test in the diagnosis of venous thrombosis. Plasma samples were taken from 104 patients undergoing venography because of clinical suspicion of lower limb venous thrombosis. The samples were assayed using a monoclonal antibody identifying an epitope on D dimer and larger crosslinked fibrin derivatives in an enzyme immunoassay. 100% of patients with positive venograms had elevated levels of these molecules. While a percentage of patients with negative venograms also had increased levels, alternative clinical explanations were apparent in most. A normal D dimer value excludes the diagnosis of venous thrombosis, while an increased value supports it. The measurement of crosslinked fibrin derivatives in plasma may play a role in the selection of patients for venography.

Keywords

Venous thrombosis - D dimer - Fibrin crosslinking - monoclonal antibodies
 

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