Download PDF
Thromb Haemost 1996; 76(03): 411-416
DOI: 10.1055/s-0038-1650592
Original Article
Schattauer GmbH Stuttgart

Haemostatic Parameters and Lifestyle Factors in Elderly Men in Italy and The Netherlands

Fransje C H Bijnen
1   The Department of Medical Physiology and Sports Medicine, Utrecht University, Utrecht, The Netherlands
2   The Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
,
Edith J M Feskens
2   The Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
,
Simona Giampaoli
3   The Laboratory of Epidemiology and Biostatistics, National Institute of Health, Rome, Italy
,
Alessandro Menotti
4   The Division of Epidemiology, University of Minnesota, Minneapolis MN, USA
,
Flaminio Fidanza
5   The Institute of Food Sciences and Nutrition, University of Perugia, Perugia, Italy
,
Gerard Hornstra
6   Department of Human Biology, University of Limburg, Maastricht, The Netherlands
,
Carl J Caspersen
7   Cardiovascular Health Studies Branch, Division of Chronic Disease Control and Community Intervention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Atlanta, Georgia, USA
,
Willem L Mosterd
1   The Department of Medical Physiology and Sports Medicine, Utrecht University, Utrecht, The Netherlands
,
Daan Kromhout
2   The Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 14 December 1995

Accepted after revision 13 May 1996

Publication Date:
10 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

The association between plasma fibrinogen, factor VII, factor X, activated partial thromboplastin time, antithrombin III and the lifestyle factors cigarette smoking, alcohol use, fat intake and physical activity was assessed in 802 men aged 70-90 years in Zutphen (The Netherlands), Montegiorgio and Crevalcore (Italy).

Smoking was positively associated with fibrinogen, also after adjustment for other lifestyle factors, age, use of anticoagulants and aspirin like drugs, body mass index, and history of myocardial infarction. Alcohol use was associated with increased levels of factor X and decreased levels of antithrombin III. Fat intake was positively associated with antithrombin III. Between cohorts, considerable differences were observed in levels of haemostatic parameters and the lifestyle factors. Compared to the mediterranean cohorts the Zutphen cohort showed the highest levels of fibrinogen and factor VII. Differences in lifestyle factors could, however, not explain differences between cohorts in levels of any of the haemostatic parameters, despite the observed associations between lifestyle factors and haemostatic parameters.

 

  • References

  • 1 Wilhelmsen L, Svardsudd K, Korsan-Bengtsen K, Larsson B, Welin L, Tibblin G. Fibrinogen as a risk factor for stroke and myocardial infarction. N Engl J Med 1984; 311: 501-505
    CrossrefPubMedGoogle Scholar
  • 2 Meade TW, Mellows S, Brozovic M, Miller GJ, Chakrabarti RR, North WRS, Haines AP, Stirling Y, Imeson JD, Thompson SG. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet 1986; 328: 533
    CrossrefPubMedGoogle Scholar
  • 3 Kannel WB, Wolf PA, Castelli WP, D’Agostino RB. Fibrinogen and risk of cardiovascular disease. The Framingham Study. JAMA 1987; 258: 1183-1186
    PubMedGoogle Scholar
  • 4 Yamell JWG, Baker IA, Sweetman PM, Bainton D, O’Brien JR, Whitehead PJ, El wood PC. Fibrinogen, viscosity, and white blood cell count are major risk factors for ischemic heart disease. The Caerphilly and Speedwell Collaborative Heart Disease Studies. Circulation 1991; 83: 836-844
    PubMedGoogle Scholar
  • 5 Heinrich J, Balleisen L, Schulte H, Assmann G, van de Loo J. Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM Study in healthy men. Arterioscler Thromb 1994; 14: 54-59
    PubMedGoogle Scholar
  • 6 Meade TW, Cooper J, Miller GJ, Howarth DJ, Stirling Y. Antithrombin III and arterial disease. Lancet 1991; 338: 850-851
    CrossrefPubMedGoogle Scholar
  • 7 Tracy RP, Bovill EG, Fried LP, Heiss G, Lee MH, Polak JF, Psaty BM, Savage PJ. The distribution of coagulation factors VII and VIII and fibrinogen in adults over 65 years. Results from the Cardiovascular Health Study. Ann Epidemiol 1992; 2: 509-519
    PubMedGoogle Scholar
  • 8 Yeh C, Pan W, Bai C, You M, Wang W, Wang L, Lee T. Curvilinear relations between age and haemostatic parameters in Chinese. Thromb Haemost 1994; 72: 239-243
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Ernst E. The role of fibrinogen as a cardiovascular risk factor. Atherosclerosis 1993; 100: 1-12
    CrossrefPubMedGoogle Scholar
  • 10 Meade TW, Imeson J, Stirling Y. Effects of changes in smoking and other characteristics on clotting factors and the risk of ischaemic heart disease. Lancet 1987; 2: 986-988
    PubMedGoogle Scholar
  • 11 Miller GJ, Cruickshank JK, Ellis LJ, Thompson RL, Wilkes HC, Stirling Y, Mitropoulos KA, Allison JV, Fox TE, Walker AO. Fat consumption and factor VII coagulant activity in middle-aged men. An association between a dietary and thrombogenic coronary risk factor. Atherosclerosis 1989; 78: 19-24
    PubMedGoogle Scholar
  • 12 Connelly JB, Roderick PJ, Cooper JA, Meade TW, Miller GJ. Positive association between self-reported fatty food consumption and factor VII coagulant activi ty, as a risk factor for coronary heart disease, in 4246 middle-aged men. Thromb Haemost 1993; 70: 250-252
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Rogers S, Yamell JW, Fehily AM. Nutritional determinants of haemostatic factors in the Caerphilly Study. Eur J Clin Nutr 1988; 42: 197-205
    PubMedGoogle Scholar
  • 14 Connelly JB, Cooper JA, Meade TW. Strenuous exercise, plasma fibrinogen, and factor VII activity. Br Heart J 1992; 67: 351-354
    CrossrefPubMedGoogle Scholar
  • 15 WHO Study Group on Epidemiology and Prevention of Cardiovascular Diseases in the Elderly. Epidemiology and prevention of cardiovascular diseases in elderly people: a report of a WHO study group (WHO Technical Report Series, No. 853). Geneva: World Health Organization 1995
    PubMedGoogle Scholar
  • 16 Pekkanen J, Mutanen M, Rasanen L, Rauramaa R, Nissinen A. Association of factor VIIc activity with dietary fat and blood lipids among elderly men. The Finnish cohorts of the Seven Countries Study. Nutr Metab Cardiovasc Dis 1995; 5: 149-154
    PubMedGoogle Scholar
  • 17 Kario K, Matsuo T, Nakao K. Factor VII hyperactivity in the elderly. Thromb Haemost 1991; 65: 25-27
    Article in Thieme ConnectPubMedGoogle Scholar
  • 18 Balleisen L, Bailey J, Epping P-H, Schulte H, van de Loo J. Epidemiological study on factor VII, factor VIII, and fibrinogen in an industrial population: I. Baseline data on the relation to age, gender, body-weight, smoking, alcohol, pill-using, and menopause. Thromb Haemost 1985; 54: 475-479
    Article in Thieme ConnectPubMedGoogle Scholar
  • 19 Stout RW, Crawford V. Seasonal variation in fibrinogen concentrations among elderly people. Lancet 1991; 338: 9-13
    CrossrefPubMedGoogle Scholar
  • 20 Woodhouse PR, Khaw KT, Plummer M, Foley A, Meade TW. Seasonal variations of plasma fibrinogen and factor VII activity in the elderly: winter infections and death from cardiovascular disease. Lancet 1994; 343: 435-439
    CrossrefPubMedGoogle Scholar
  • 21 Keys A, Aravanis C, Blackburn HW, van Buchem FSP, Buzina R, Djordjevic BS, Dontas AS, Fidanza F, Karvonen MJ, Kimura N, Lekos D, Monti M, Puddu V, Taylor HL. Epidemiological studies related to coronary heart disease: characteristics of men aged 40-59 in seven countries. Acta Med Scand 1967; 460 (Suppl) 1-392
    PubMedGoogle Scholar
  • 22 Clauss A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol 1957; 17: 237-246
    CrossrefPubMedGoogle Scholar
  • 23 van Dam-Mieras MCE, Muller AD, Hemker HC. Blood coagulation factors II, V, VII, VIII, IX, X, XI. Determination by clotting assays. In: Methods of Enzymatic Analysis, vol 5. Bergmeier HU, Bergmeier J, Grassl M. (eds). Weinheim: Verlag Chemie GmbH: 1984: 352-365
  • 24 Bas BM, Costongs GMPJ, Janson PCW. Rapid determination of five coagulation parameters in one sample with a centrifugal analyzer. Haemostasis 1987; 17: 260-267
    PubMedGoogle Scholar
  • 25 Huijbregts PPCW, Feskens EJM, Rasanen L, Alberti-Fidanza A, Mutanen M, Fidanza F, Kromhout D. Dietary intake in five ageing cohorts of men in Finland, Italy and the Netherlands. Eur J Clin Nutr 1995; 49: 852-860
    PubMedGoogle Scholar
  • 26 Caspersen CJ, Bloemberg BPM, Saris WHM, Merritt RK, Kromhout D. The prevalence of selected physical activities and their relation with coronary heart disease risk factors in elderly men: the Zutphen Study, 1985. Am J Epidemiol 1991; 133: 1078-1092
    CrossrefPubMedGoogle Scholar
  • 27 Westerterp KR, Saris WHM, Bloemberg BPM, Kempen K, Caspersen CJ, Kromhout D. Validation of the Zutphen Physical Activity Questionnaire for the Elderly with doubly labeled water. (Abstract no. 403). Med Sci Sports Exerc 1992; 23: S68
    PubMedGoogle Scholar
  • 28 Bijnen FCH, Feskens EJM, Caspersen CJ, Giampaoli S, Nissinen AM, Menotti A, Mosterd WL, Kromhout D. Physical activity and cardiovascular risk factors among elderly men in Finland, Italy and the Netherlands. Am J Epidemiol 1996; 143: 553-561
    CrossrefPubMedGoogle Scholar
  • 29 Rose GA, Blackburn H. Cardiovascular survey methods. Geneva: World Health Organization 1968
    PubMedGoogle Scholar
  • 30 Iso H, Folsom AR, Sato S, Wu KK, Shimamoto T, Koike K, Iida M, Komachi Y. Plasma fibrinogen and its correlates in Japanese and US population samples. Arterioscler Thromb 1993; 13: 783-790
    CrossrefPubMedGoogle Scholar
  • 31 Folsom AR, Davis CE, Marcucci G, Wu KK, Palareti G, Poggi M, Coccheri S, Illingworth K, Ernst E, Stout RW. Seasonal fibrinogen fluctuations among elderly people (letter). Lancet 1991; 338: 629-630
    CrossrefPubMedGoogle Scholar
  • 32 Kannel WB, D’Agostino RB, Belanger AJ. Fibrinogen, cigarette smoking, and risk of cardiovascular disease: insights from the Framingham Study. Am Heart J 1987; 113: 1006-1010
    CrossrefPubMedGoogle Scholar
  • 33 Krobot K, Hense HW, Cremer P, Eberle E, Keil U. Determinants of plasma fibrinogen: relation to body weight, waist-to-hip ratio, smoking, alcohol, age, and sex. Results from the Second MONICA Augsburg Survey, 1989-1990. Arterioscler Thromb 1992; 12: 780-788
    PubMedGoogle Scholar
  • 34 De Boever E, De Bacquer D, Braeckman L, Baele G, Rosseneu M, De Backer G. Relation of fibrinogen to lifestyles and to cardiovascular risk factors in a working population. Int J Epidemiol 1995; 24: 915-921
    CrossrefPubMedGoogle Scholar
  • 35 Bladbjerg EM, Marckmann P, Sandstrom B, Jespersen J. Non-fasting factor VII coagulant activity (FVII:C) increased by high-fat diet. Thromb Haemost 1994; 71: 755-758
    Article in Thieme ConnectPubMedGoogle Scholar
  • 36 Shahar E, Folsom AR, Wu KK, Dennis BH, Shimakawa T, Conlan MG. et al Associations of fish intake and dietary n-3 polyunsaturated fatty acids with a hypocoagulable profile. The Atherosclerosis Risk in Communities (ARIC) Study. Arterioscler Thromb 1993; 13: 1205-1212
    PubMedGoogle Scholar
  • 37 Miller GJ, Martin JC, Mitropoulos KA, Reeves BEA, Thompson RL, Meade TW, Cooper JA, Cruickshank JK. Plasma factor VII is activated by postprandial triglyceridaemia, irrespective of dietary fat composition. Atherosclerosis 1991; 86: 163-171
    CrossrefPubMedGoogle Scholar
  • 38 Rankinen T, Rauramaa R, Vaisanen S, Penttila IM, Uusitupa M. Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors. Thromb Haemost 1994; 71: 180-183
    Article in Thieme ConnectPubMedGoogle Scholar
  • 39 Folsom AR, Conlan MG, Davis CE, Wu KK. Relations between haemostasis variables and cardiovascular risk factors in middle-aged adults. Ann Epidemiol 1992; 2: 481-494
    CrossrefPubMedGoogle Scholar
  • 40 Mpller L, Kristensen TS. Plasma fibrinogen and ischemic heart disease risk factors. Arterioscler Thromb 1991; 11: 344-350
    CrossrefPubMedGoogle Scholar
  • 41 Lakka TA, Salonen JT. Moderate to high intensity conditioning leisure time physical activity and high cardiorespiratory fitness are associated with reduced plasma fibrinogen in eastern Finnish men. J Clin Epidemiol 1993; 46: 1119-1127
    CrossrefPubMedGoogle Scholar
  • 42 Elwood PC, Yarnell JWG, Pickering J, Fehily AM, O’Brien JR. Exercise, fibrinogen, and other risk factors for ischaemic heart disease. Caerphilly Prospective Heart Disease Study. Br Heart J 1993; 69: 183-187
    PubMedGoogle Scholar
  • 43 Streiff M, Bell WR. Exercise and hemostasis in humans. Seminars in Hematology 1994; 31: 155-165
    PubMedGoogle Scholar
  • 44 Suzuki T, Yamauchi K, Yamada Y, Furumichi T, Furui H, Tsuzuki J, Hayashi H, Sotobata I, Saito H. Blood coagulability and fibrinolytic activity before and after physical training during the recovery phase of acute myocardial infarction. Clin Cardiol 1992; 15: 358-364
    CrossrefPubMedGoogle Scholar
  • 45 Wosomu D, Allardyce W, Ballantyne D, Tansey P. Influence of power and aerobic exercise training on haemostatic factors after coronary artery surgery. Br Heart J 1992; 68: 181-186
    CrossrefPubMedGoogle Scholar
  • 46 Schneider SH, Kim HC, Khachadurian AK, Ruderman NB. Impaired fibrinolytic response to exercise in type II diabetes: effects of exercise and physical training. Metabolism 1988; 37: 924-929
    CrossrefPubMedGoogle Scholar