Adenine Nucleotides in Platelets from Normal and Uraemic Subjects

Summary

Adenine nucleotides in platelets from normal and uraemic subjects were measured before and after passage of blood through glass bead filters. Platelets from uraemic subjects contained normal amounts of ATP, ADP, AMP and total nucleotides. Normal platelets which had passed through filters contained higher concentrations of ATP, ADP and total nucleotides than platelets in control blood samples, indicating either heterogeneity of adenine nucleotide content in normal platelets or possibly adsorption of nucleotides onto platelets during their passage through the filters. This phenomenon was not observed with platelets from uraemic patients.

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