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Thromb Haemost 1981; 45(03): 230-232
DOI: 10.1055/s-0038-1650176
Original Article
Schattauer GmbH Stuttgart

Effect of Local Urokinase on Arterial Occlusion of Lower Limbs

J-N Fiessinger
*   The Chaire de Clinique Médicale et de Pathologie Vasculaire (Pr. E. Housset), Paris, France
,
M Aiach
**   et Département d'Hémostase, Laboratoire de Biochimie (Pr. M. Leclerc) Hôpital Broussais, Paris, France
,
L Capron
*   The Chaire de Clinique Médicale et de Pathologie Vasculaire (Pr. E. Housset), Paris, France
,
M Devanlay
**   et Département d'Hémostase, Laboratoire de Biochimie (Pr. M. Leclerc) Hôpital Broussais, Paris, France
,
M Vayssairat
*   The Chaire de Clinique Médicale et de Pathologie Vasculaire (Pr. E. Housset), Paris, France
,
Y Juillet
*   The Chaire de Clinique Médicale et de Pathologie Vasculaire (Pr. E. Housset), Paris, France
› Author Affiliations
Further Information

Publication History

Received 11 February 1981

Accepted 18 March 1981

Publication Date:
06 July 2018 (online)

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Summary

Sixty nine patients were treated with local intra-arterial urokinase (37,500 U/CTA. hr-1) for recent severe ischemia of lower limbs: 27 (40%) ultimately required amputation. The difference of amputation rate between the groups with and without thrombolysis was not significant (33% v. 42%). A biological study in 6 patients showed that local arterial plasminemia occurred in only 1 patient. Local urokinase does not strongly stimulate “endogenous” thrombolysis and enhances “exogenous” thrombolysis only very inconstantly. A better adaptation of urokinase dosage or the use of an agent with a higher affinity for fibrin might improve the efficiency of local thrombolytic therapy.

Keywords

Thrombolysis - Urokinase - Local urokinase - Lower limbs ischemia
 

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