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Thromb Haemost 1981; 45(01): 034-037
DOI: 10.1055/s-0038-1650124
Original Article
Schattauer GmbH Stuttgart

International Collaborative Study on the Assay of Commercially Available High and Low Molecular Weight Urokinases

P J Gaffney
The National Institute for Biological Standards and Control, Holly Hill, Hampstead, London, U. K
,
S M Tydeman
The National Institute for Biological Standards and Control, Holly Hill, Hampstead, London, U. K
,
T B L Kirkwood
The National Institute for Biological Standards and Control, Holly Hill, Hampstead, London, U. K
,
D Aronson
*   The Bureau of Biologies, Department of Health, Education, and Welfare, Food and Drug Administration, Bethesda, Maryland, U.S.A
,
G Murano
*   The Bureau of Biologies, Department of Health, Education, and Welfare, Food and Drug Administration, Bethesda, Maryland, U.S.A
› Author Affiliations
Further Information

Publication History

Received 24 August 1980

Accepted 17 November 1980

Publication Date:
04 July 2018 (online)

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Summary

Urokinases of different molecular weights are now commercially available. An international collaborative study (eight laboratories) has been conducted to investigate the effect of type and concentration of plasminogen on the assay of two different urokinase preparations against the International Reference Preparation (IRP). Considerable inter-laboratory variation in relative potency estimation was found, and a small effect of plasminogen concentration, independent of type, was apparent.

Keywords

Assay - Urokinases - High and low-molecular weight
 

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