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DOI: 10.1055/s-0038-1650107
Monitoring of Oral Anticoagulation by an Amidolytic Factor X Assay
A Long-Term Study in 42 PatientsPublikationsverlauf
Received 22. Juli 1980
Accepted 03. Oktober 1980
Publikationsdatum:
13. Juli 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/198001/lookinside/thumbnails/10-1055-s-0038-1650107-1.jpg)
Summary
The validity of the amidolytic Factor X assay for the control of long term oral anticoagulation (OA) was investigated in 42 patients randomized into 2 groups; PT group (anticoagulant dosage according to PT) and F. X group (anticoagulant dosage based on F. X). An independent expert's dosage according to F. X served for analysis in the former group. In the F. X group the F. X based dosage was considered valid only when not differing by more than 15% from the expert's PT based dosage.
Confirming the good correlation between PT and F. X the study further demonstrates that the changes from one control to the next one, ΔPT and ΔF. X, too, are significantly correlated (r = 0.58, p & 0.001, n = 217). In over one third of the periods the dosage proposals based on PT and F. X were identical and differed by more than 15% in only 12/217 instances.
Our results justify a large trial on the control of OA by the amidolytic F. X assay.
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References
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