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Thromb Haemost 1993; 70(06): 0900-0902
DOI: 10.1055/s-0038-1649696
Original Article
Clinical Studies
Schattauer GmbH Stuttgart

Lipopolysaccharide Induced Monocyte Thromboplastin Synthesis and Coagulation Responses in Patients Undergoing Coronary Bypass Surgery after Preoperative Supplementation with n-3 Fatty Acids

D W T Nilsen
The Institute of Medical Biology, University of Tromsø, Norway
,
S M Almdahl
1   The Department of Surgery, University of Tromsø, Norway
,
B Svensson
The Institute of Medical Biology, University of Tromsø, Norway
,
J Vaage
1   The Department of Surgery, University of Tromsø, Norway
,
K Rasmussen
The Institute of Medical Biology, University of Tromsø, Norway
,
B Østerud
2   The Institute of Medical Biology, University of Tromsø, Norway
› Author Affiliations
Further Information

Publication History

Received 03 November 1992

Accepted after revision 17 August 1993

Publication Date:
06 July 2018 (online)

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Summary

Twenty patients with coronary heart disease (CHD) and elevated serum lipids were randomized into 2 groups of 10 to receive encapsulated preparations of either a concentrated ethylester form of eicosapentaenoic acid (EPA) and docosa-hexaenoic acid (DHA) or corn oil in doses of 6 g per day, given double blindly for approximately two months prior to coronary bypass surgery. Lipopolysaccharide (LPS) induced monocyte thromboplastin synthesis was studied during the preoperative period and one week following surgery. The ability of n-3 fatty acids to modify tissue factor pathway inhibitor (TFPI) and tissue plasminogen activator inhibitor (PAI-1) was also evaluated along with fibrinogen and thrombin-antithrombin III (TAT) complexes.

No significant changes were noted preoperatively. Monocyte reactivity, PAI-1, fibrinogen and TAT increased significantly after surgery. These changes were not modified by preoperative loading with n-3 fatty acids.

 

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