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Thromb Haemost 1993; 70(04): 712-716
DOI: 10.1055/s-0038-1649655
Original Article
Animal Models
Schattauer GmbH Stuttgart

Surgery and Environmental Influence as Risk-Factors for the Development of Deep Vein Thrombosis in Animal Experiments

R Hoffmann
The Department of Surgery (Head: Prof. Dr. F. Largiadèr), University Hospital of Zurich, Switzerland
,
R C Schimmer
The Department of Surgery (Head: Prof. Dr. F. Largiadèr), University Hospital of Zurich, Switzerland
,
F Largiadèr
The Department of Surgery (Head: Prof. Dr. F. Largiadèr), University Hospital of Zurich, Switzerland
› Author Affiliations
Further Information

Publication History

Received 04 February 1993

Accepted after revision 28 May 1993

Publication Date:
05 July 2018 (online)

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Summary

The aim of this experimental study was to determine whether deep vein thrombosis (DVT) in animals occurs after osteosynthesis of the femur, and whether a postoperative drop in air pressure increases the frequence of DVT Thus, osteosynthesis of the femur was performed in 10 New Zealand rabbits. Postoperatively a drop in air pressure of 300 hPA was induced. After 40 h in the pressure cabin ascending phlebography was performed (Group A). In a control-group of 10 other rabbits surgery was performed without postoperative drop in air pressure (Group B) while in a second control only the drop in air pressure was induced without surgery (Group C).

The phlebographic studies showed DVT in 4 out of 10 rabbits in group A. In group B there was no demonstrable DVT while in group C one ease of DVT was seen. The difference between group A and group B and C is statistically significant. In conclusion, a rapid drop in air pressure seems to have significant impact on the pathogenesis of DVT in rabbits after osteosynthesis of the femur.

 

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