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Thromb Haemost 1966; 15(03/04): 428-435
DOI: 10.1055/s-0038-1649444
Originalarbeiten — Original Articles — Travaux Originaux
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The Clot-Promoting Effect of Adenosine-5’- Diphosphate (ADP). I. Mechanisms of Action

J Pizzuto   *
1   Department of Medicine and Laboratory for the Study of Hereditary and Metabolic Disorders University of Utah College of Medicine, Salt Lake City, Utah, U.S.A
,
A.J Giorgio
1   Department of Medicine and Laboratory for the Study of Hereditary and Metabolic Disorders University of Utah College of Medicine, Salt Lake City, Utah, U.S.A
,
P Didisheim   **
1   Department of Medicine and Laboratory for the Study of Hereditary and Metabolic Disorders University of Utah College of Medicine, Salt Lake City, Utah, U.S.A
› Author Affiliations
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

1. ADP accelerates blood coagulation by at least two mechanisms. One is by causing release of coagulant phospholipids from platelets. The other is by activation of a plasma coagulation factor whose action is early in thromboplastin generation.

2. Possible mechanisms of ADP’s effect on blood coagulation are discussed.

3. These findings suggest that ADP may play a more significant role in the mechanisms of hemostasis and in the pathophysiology of thrombosis than has heretofore been supposed.

* Present address: Hospital de Enfermedades de la Nutricion, Mexico City, Mexico.


** Present address: Mayo Clinic, Rochester, Minn., U.S.A.


 

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