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Thromb Haemost 1966; 15(01/02): 084-092
DOI: 10.1055/s-0038-1649413
Originalarbeiten — Original Articles — Travaux Originaux
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Adhesiveness of Blood Platelets in Uremia[*]

E. W Salzman   **
1   Department of Surgery, Harvard Medical School and Surgical Services, Massachusetts General Hospital, Boston, Mass., U.S.A
,
Lena L. Neri
1   Department of Surgery, Harvard Medical School and Surgical Services, Massachusetts General Hospital, Boston, Mass., U.S.A
› Author Affiliations
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

Platelet adhesiveness, measured by an in vitro technique, has been found abnormal in 21 of 24 patients with chronic renal failure. This abnormality was strongly correlated with prolongation of the Ivy bleeding time, with abnormal prothrombin consumption, and with clinical bleeding.

The possible pathogenesis of this defect is discussed.

Supported by grants from the Massachusetts Heart Association and the National Heart Institute of the II. S. Public Health Service.


* Presented in part at the Xth Congress of the International Society of Hematology, Stockholm, 1964.


** Fellow of the Medical Foundation, Inc., Boston.


 

  • References

  • 1 Altschuler G, Marcus A. J, Ullman H. C. Platelets and platelet phosphatides in uremia. Blood 16: 1439 1960;
    PubMedGoogle Scholar
  • 2 Born G. V. R. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature (Lond) 194: 927 1962;
    PubMedGoogle Scholar
  • 3 Caen J. Adhesion des plaquettes aux lèvres de la plaie vasculaire et aggrégation entre elle. Proc. XXII Congr. Internat. Union Physiol. Sei., Leiden 1962; 248.
    PubMedGoogle Scholar
  • 4 Cahalane S. F, Johnson S. A, Monto R. W, Caldwell M. J. Acquired thrombocytopathy : observations on coagulation defect in uremia. Amer. J. clin. Path 30: 507 1958;
    PubMedGoogle Scholar
  • 5 Cheney K, Bonnin J. A. Haemorrhage, platelet dysfunction, and other coagulation defects in uremia. Brit. J. Haematol 08: 215 1962;
    CrossrefPubMedGoogle Scholar
  • 6 Donner L, Neuwirtova R. Hemostatic defect of acute and chronic uremia. Thrombos. Diathes. haemorrh. (Stuttg) 05: 319 1960;
    PubMedGoogle Scholar
  • 7 Hardisty R. M, Dormandy K. M, Hutton R. A. Thrombasthenia: Studies on three cases. Brit. J. Haematol 10: 371 1964;
    CrossrefPubMedGoogle Scholar
  • 8 Hellem A. J. Adhesiveness of human blood platelets in vitro. Scand. J. clin. Lab. Invest. 12. 51 1960
    PubMedGoogle Scholar
  • 9 Hellem A. J, Ödegaard A. E, Sålhegg B. A. Platelet adhesiveness in chronic renal failure. Xth Congress of Internat. Soc. Hematol., Stockholm. 1964
    PubMedGoogle Scholar
  • 10 Ivy A. C, Nelson D, Bucher G. Standardization of certain factors in the cutaneous “venestasis” bleeding time technique. J. Lab. clin. Med 26: 1812 1941;
    PubMedGoogle Scholar
  • 11 Kuhlbäck B. Bleeding tendency in chronic renal failure. Acta med. scand 157: 174 1957;
    PubMedGoogle Scholar
  • 12 Larrain C, Adelson E. Hemostatic defect of uremia. Blood 11: 1059 1956;
    PubMedGoogle Scholar
  • 13 Lewis J. H, Zucker M. B, Ferguson J. H. Bleeding tendency in uremia. Blood 11: 1073 1956;
    CrossrefPubMedGoogle Scholar
  • 14 Merskey C. Laboratory diagnosis of haemophilia. J. clin. Path 03: 301 1950;
    CrossrefPubMedGoogle Scholar
  • 15 Rath C. E, Maillard J. A, Schreiner G. E. Bleeding tendency in uremia. New Engl. J. Med 257: 808 1957;
    CrossrefPubMedGoogle Scholar
  • 16 Salzman E. W. Measurement of platelet adhesiveness. J. Lab. clin. Med 62: 724 1963;
    PubMedGoogle Scholar
  • 17 Strehler B. C, Totter J. R. In: Methods of Biochemical Analysis. Ed. Glick D. 01 341 1954. Interscience; London.:
    Google Scholar
  • 18 Willoughby M. L. N, Crouch S. Haemorrhagic tendency in renal failure. Brit. J. Haematol 07: 315 1961;
    CrossrefPubMedGoogle Scholar