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DOI: 10.1055/s-0038-1649211
Immunoelectrophoretic Studies on the Kinetics of Plasmic Degradation of Human Fibrinogen[*]
Publication History
Received 06 November 1975
Accepted 20 July 1976
Publication Date:
03 July 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/197701/lookinside/thumbnails/10-1055-s-0038-1649211-1.jpg)
Summary
In vitro degradation of fibrinogen results in the appearance of an early fragment, different in its electrophoretic mobility to that of fragments X, Y, D and E.
It reacts with antifibrinogen antiserum, does not react with anti-D antiserum and it is anti-genically related to fragment E.
Compared with terminal fragment E, it migrates more slowly towards the anode, it appears earlier and in a greater concentration at the beginning, decreasing and disappearing during degradation.
The antigen antibody crossed electrophoresis was used in these experiments, but to distinguish the fragments from already known X, Y or even fibrinogen, the applying of an intermediate gel with anti D was of great value.
* Presented in part at the Vth Congress of the International Society on Thrombosis and Haemostasis, Paris 1975.
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