In Vivo Labeling of Platelets with ⁷⁵Se – Selenomethionine in Patients with Hepatic Cirrhosis and Thrombocytopenia.

Summary

Labeling of platelets in vivo by ⁷⁵Se – Selenomethionine (⁷⁵Se-M) was performed in nine cases of hepatic cirrhosis and thrombocytopenia for evaluation of the kinetics of platelet maturation. Folic acid and vitamin B₁₂ deficiency was excluded by pretreatment of the patients with these agents. The platelet maturation time – time between the injection of the isotope and maximum radioactivity of separated blood platelets – was shortened to 7.7±1.1 days (mean±SD) compared to the normal of 9.1±1.4 days. For explanation a disturbance of megakaryocyte maturation and/or platelet release from the bone marrow is suggested.

• References

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