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Thromb Haemost 1994; 72(06): 869-873
DOI: 10.1055/s-0038-1648976
Original Article
Schattauer GmbH Stuttgart

Possible Structural Implications of 20 Mutations in the Protein C Protease Domain

Judith S Greengard
The Departments of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
,
John H Griffin
The Departments of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
,
Cindy L Fisher
The Departments of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
› Author Affiliations
Further Information

Publication History

Received 30 May 1994

Accepted after revision 08 August 1994

Publication Date:
06 July 2018 (online)

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Summary

Analysis of naturally occurring protein mutations yields valuable insights into functionally important sequences. Characterizing mutations responsible for protein C deficiency at the molecular level has been the subject of intensive investigation. In a previous study, a three-dimensional model of the serine protease domain of protein C was used to analyze the set of protease domain mutations previously available. The mutations were largely found to fall into a limited number of categories. A recently updated protein C mutation data base has provided a number of new mutations which have been analyzed for structural predictions.

 

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