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Thromb Haemost 1994; 72(06): 869-873
DOI: 10.1055/s-0038-1648976
DOI: 10.1055/s-0038-1648976
Original Article
Possible Structural Implications of 20 Mutations in the Protein C Protease Domain
Further Information
Publication History
Received 30 May 1994
Accepted after revision 08 August 1994
Publication Date:
06 July 2018 (online)


Summary
Analysis of naturally occurring protein mutations yields valuable insights into functionally important sequences. Characterizing mutations responsible for protein C deficiency at the molecular level has been the subject of intensive investigation. In a previous study, a three-dimensional model of the serine protease domain of protein C was used to analyze the set of protease domain mutations previously available. The mutations were largely found to fall into a limited number of categories. A recently updated protein C mutation data base has provided a number of new mutations which have been analyzed for structural predictions.