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Thromb Haemost 1994; 72(05): 682-684
DOI: 10.1055/s-0038-1648942
Original Article
Schattauer GmbH Stuttgart

Long-Term Stability Studies on the WHO IRP for Thromboplastin (Human Plain BCT/253)

L Poller
1   The UK Reference Laboratory for Anticoagulant Reagents and Control, Withington Hospital, Manchester, UK
,
Jean Pulford
1   The UK Reference Laboratory for Anticoagulant Reagents and Control, Withington Hospital, Manchester, UK
,
K J Stevenson
1   The UK Reference Laboratory for Anticoagulant Reagents and Control, Withington Hospital, Manchester, UK
,
P Cooper
2   The Royal Hallamshire Hospital, Sheffield, UK
,
G Gamble
3   The Coventry and Warwickshire Hospital, Coventry, UK
,
Jean M Thomson
1   The UK Reference Laboratory for Anticoagulant Reagents and Control, Withington Hospital, Manchester, UK
› Author Affiliations
Further Information

Publication History

Received 17 July 1992

Accepted after resubmission 19 July 1994

Publication Date:
06 July 2018 (online)

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Summary

Long-term stability studies on the WHO second primary International Reference Preparation (IRP) for thromboplastin (human plain BCT/253) stored at ™20° C have been conducted for ten years.

Three centres took part in the exercise using frozen normal and coumarinised plasma samples which were tested throughout. There has been no measurable change in the prothrombin time performance of the human plain IRP over the ten-year period. It can therefore be concluded that new IRP may continue to be calibrated against this preparation in accord with WHO recommendations.

 

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