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Thromb Haemost 1978; 40(02): 518-531
DOI: 10.1055/s-0038-1648685
Original Article
Schattauer GmbH Stuttgart

Platelet Functions in Relation to Dietary Fats in Farmers from two Regions of France[*]

S Renaud
The INSERM, Unité 63, Lyon-Bron, France and the Department of Nutrition, University of Montreal, Montreal, Canada
,
E Dumont
The INSERM, Unité 63, Lyon-Bron, France and the Department of Nutrition, University of Montreal, Montreal, Canada
,
F Godsey
The INSERM, Unité 63, Lyon-Bron, France and the Department of Nutrition, University of Montreal, Montreal, Canada
,
A Suplisson
The INSERM, Unité 63, Lyon-Bron, France and the Department of Nutrition, University of Montreal, Montreal, Canada
,
C Thevenon
The INSERM, Unité 63, Lyon-Bron, France and the Department of Nutrition, University of Montreal, Montreal, Canada
› Author Affiliations
Further Information

Publication History

Received 21 June 1977

Accepted 09 April 1978

Publication Date:
12 July 2018 (online)

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Summary

To determine whether the long-term feeding of dietary fats affect platelet functions in man, platelet aggregation (to thrombin ADP, collagen, epinephrine) and clotting activity of platelet-rich plasma (PRP), platelet-poor plasma and of washed platelets, were studied in a mobile-laboratory in 44 healthy male farmers (40-45 years) from two French regions Var and Moselle, in relation to lipemia, glycemia, dietary nutriments, and platelet phospholipid composition. In the Moselle subjects, the platelet clotting activity of PRP and of washed platelets, the platelet aggregation to thrombin and ADP, were highly significantly (p <0.001) increased as compared to those of Var, but not the plasma cholesterol, which was identical in the two regions.

In Moselle, the intake of total calories, total lipids and saturated fats was higher than in the Var.

However, it was only with the saturated fat intake (mostly stearic acid) that the platelet clotting activity (p <0.01) and the platelet aggregation (p <0.001) were highly significantly correlated. The platelet clotting activity was also significantly (p <0.001) correlated with the fatty acid composition of the platelet phospholipid fractions phosphatidyl serine + phosphatidyl inositol.

* Presented in part at the IVth International Symposium on Atherosclerosis, August 1976, Tokyo, Japan and at the 50th meeting of the American Heart Association, November 1977, Miami, USA.


 

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