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DOI: 10.1055/s-0038-1648490
Measurement of Markers of Activated Coagulation in Antithrombin III Deficient Subjects
Publikationsverlauf
Received 02. September 1991
Accepted after revision 28. November 1991
Publikationsdatum:
03. Juli 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/199205/lookinside/thumbnails/10-1055-s-0038-1648490-1.jpg)
Summary
Functional antithrombin III levels were measured by factor Xa inhibition in 63 members of a large family with type 2 antithrombin III deficiency and individuals were classified as antithrombin III deficient or non-deficient according to the results. FI+2 and TAT complexes were measured using an ELISA and FPA levels were measured by radioimmunoassay.
Thirty subjects (48%) were classified as antithrombin III deficient and 33 (52%) as antithrombin III non-deficient. The mean level of FI+2 was significantly higher in the deficient adults (0.87 ± 0.26) compared to both the non-deficient adults (0.70 ± 0.21) (p = 0.03) and the deficient adults receiving warfarin (0.16 ± 0.01) (p <0.001). The differences in the mean values of TAT complexes and FPA between deficient and non-deficient individuals were not statistically significant.
These findings suggest that untreated antithrombin III deficient subjects generate more thrombin than their non-deficient family members and that warfarin inhibits this thrombin formation. In this cross-sectional study, it is not possible to correlate the levels of the surrogate makers with future clinical outcome.
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